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Database: UniProt
Entry: A4HHJ9_LEIBR
LinkDB: A4HHJ9_LEIBR
Original site: A4HHJ9_LEIBR 
ID   A4HHJ9_LEIBR            Unreviewed;       749 AA.
AC   A4HHJ9;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=SAM-dependent MTase RsmB/NOP-type domain-containing protein {ECO:0000259|Pfam:PF01189};
GN   ORFNames=LBRM_29_1970 {ECO:0000313|EMBL:CAM40053.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40053.1, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM40053.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40053.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM40053.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40053.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR799004; CAM40053.1; -; Genomic_DNA.
DR   RefSeq; XP_001566540.1; XM_001566490.1.
DR   AlphaFoldDB; A4HHJ9; -.
DR   STRING; 5660.A4HHJ9; -.
DR   GeneID; 5417429; -.
DR   KEGG; lbz:LBRM_29_1970; -.
DR   VEuPathDB; TriTrypDB:LbrM.29.1970; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_290026100; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_290026200; -.
DR   InParanoid; A4HHJ9; -.
DR   OMA; CEDGCIP; -.
DR   Proteomes; UP000007258; Chromosome 29.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR22807:SF16; S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN; 1.
DR   Pfam; PF01189; Methyltr_RsmB-F; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          554..605
FT                   /note="SAM-dependent MTase RsmB/NOP-type"
FT                   /evidence="ECO:0000259|Pfam:PF01189"
FT   REGION          513..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        524..552
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   749 AA;  80189 MW;  6E283926D6AE13E5 CRC64;
     MTPPLQAQCI DTSSPQLVIQ RSLGQFLRSG SECVCVCTCA PVMAEGATDA TPCGYPRTFS
     AELIRHCEDG CIPPEVFVDA RVLLDDEHRR RYVRINPRCE ERVLDVGAEV VMRPETALQS
     ALMDTSTWLF PEEGKVADTL EAAVRAGTTT TPSKAADGAG ISQWGIHCTC GTVPRAIVLR
     LGLAGLTGLP LASVEPVAWL PCGVFALPWS YAMGDSPLFH DGTLIAMDAA SIAAVVALHP
     RKGDRVLDLC CAPGMKLGLL ADAVTRGHTG GACSPLSAVS PPLIDGIAVG VDVNLSRLYM
     ARSTLKKQQQ QPKHQGHSTT GTQPSLPVCL FAGDGCRFSL GSAAAALNLT GSVVNVGTGL
     TTEEKRRLQR QHDTTAITAR WNRRRSTLKE ALSAGPHEAE SSPPPYVVYA PSYARTLLAT
     WLQEKACGLQ TTDSTAPLPQ PQPLLFDRVL VDAECSHDGS VAHMQLDEQH ESTTDAVNDS
     ASGKHVAWSA ASTIQKGRGV DNEYRMHHMN LGVSSDGVES NREKAPLVSS QPLSSFHAGS
     SEQSTAEAPP SSSASLFALQ SGLLDNGYRQ LRPGGTLLYA TCSYSYLQNE YVVRRFLERA
     NAVAEKAEEG DAGSTLTGCD APRRVMAVLV PAFSYAHEED EKSVSRVAGD DGVAACIRVD
     SEAQRHDVQR LLDAHAFDYG TVQRGHARYV SLEGLDRSVS SADEHVALGS RFWPRIFRSS
     FLYVAKIWKK PLDVAVSVKD GSGGMGNDK
//
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