ID A4HHJ9_LEIBR Unreviewed; 749 AA.
AC A4HHJ9;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=SAM-dependent MTase RsmB/NOP-type domain-containing protein {ECO:0000259|Pfam:PF01189};
GN ORFNames=LBRM_29_1970 {ECO:0000313|EMBL:CAM40053.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40053.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40053.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40053.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40053.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40053.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799004; CAM40053.1; -; Genomic_DNA.
DR RefSeq; XP_001566540.1; XM_001566490.1.
DR AlphaFoldDB; A4HHJ9; -.
DR STRING; 5660.A4HHJ9; -.
DR GeneID; 5417429; -.
DR KEGG; lbz:LBRM_29_1970; -.
DR VEuPathDB; TriTrypDB:LbrM.29.1970; -.
DR VEuPathDB; TriTrypDB:LBRM2903_290026100; -.
DR VEuPathDB; TriTrypDB:LBRM2903_290026200; -.
DR InParanoid; A4HHJ9; -.
DR OMA; CEDGCIP; -.
DR Proteomes; UP000007258; Chromosome 29.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22807:SF16; S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 554..605
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|Pfam:PF01189"
FT REGION 513..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 80189 MW; 6E283926D6AE13E5 CRC64;
MTPPLQAQCI DTSSPQLVIQ RSLGQFLRSG SECVCVCTCA PVMAEGATDA TPCGYPRTFS
AELIRHCEDG CIPPEVFVDA RVLLDDEHRR RYVRINPRCE ERVLDVGAEV VMRPETALQS
ALMDTSTWLF PEEGKVADTL EAAVRAGTTT TPSKAADGAG ISQWGIHCTC GTVPRAIVLR
LGLAGLTGLP LASVEPVAWL PCGVFALPWS YAMGDSPLFH DGTLIAMDAA SIAAVVALHP
RKGDRVLDLC CAPGMKLGLL ADAVTRGHTG GACSPLSAVS PPLIDGIAVG VDVNLSRLYM
ARSTLKKQQQ QPKHQGHSTT GTQPSLPVCL FAGDGCRFSL GSAAAALNLT GSVVNVGTGL
TTEEKRRLQR QHDTTAITAR WNRRRSTLKE ALSAGPHEAE SSPPPYVVYA PSYARTLLAT
WLQEKACGLQ TTDSTAPLPQ PQPLLFDRVL VDAECSHDGS VAHMQLDEQH ESTTDAVNDS
ASGKHVAWSA ASTIQKGRGV DNEYRMHHMN LGVSSDGVES NREKAPLVSS QPLSSFHAGS
SEQSTAEAPP SSSASLFALQ SGLLDNGYRQ LRPGGTLLYA TCSYSYLQNE YVVRRFLERA
NAVAEKAEEG DAGSTLTGCD APRRVMAVLV PAFSYAHEED EKSVSRVAGD DGVAACIRVD
SEAQRHDVQR LLDAHAFDYG TVQRGHARYV SLEGLDRSVS SADEHVALGS RFWPRIFRSS
FLYVAKIWKK PLDVAVSVKD GSGGMGNDK
//