ID A4HI91_LEIBR Unreviewed; 552 AA.
AC A4HI91;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM40300.1};
GN ORFNames=LBRM_30_1510 {ECO:0000313|EMBL:CAM40300.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40300.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40300.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40300.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40300.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40300.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799005; CAM40300.1; -; Genomic_DNA.
DR RefSeq; XP_001566781.1; XM_001566731.1.
DR AlphaFoldDB; A4HI91; -.
DR STRING; 5660.A4HI91; -.
DR GeneID; 5417676; -.
DR KEGG; lbz:LBRM_30_1510; -.
DR VEuPathDB; TriTrypDB:LbrM.30.1510; -.
DR VEuPathDB; TriTrypDB:LBRM2903_300020900; -.
DR InParanoid; A4HI91; -.
DR OMA; CGHTEWV; -.
DR Proteomes; UP000007258; Chromosome 30.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19848:SF7; F-BOX AND WD-40 DOMAIN PROTEIN 7; 1.
DR PANTHER; PTHR19848; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 297..333
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 344..383
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 58244 MW; BB3FB37445B239E1 CRC64;
MYSQGGSAAS GAPGGHRSNT GTTDPGAPTR IRSIGRPSGA VRDSVAGGPR SSVGRLRTSS
PSTTAAVGRD RRPLGRGPVP TQFTPLSTQC CSSEAVPRAT AGHSTAHDTI QAEMDALADE
FYGSAPSQAP RDGATVPRAP AFATSADSPY YRANAEIGLT ADTLHSTTSW YEGPADSTGR
IFDASDSNLL CMDVLVPPAA APGAVVRAPA SRAFGAAPPS ASSPLCVVGS ADHGLRVFDL
CTMRELKMLY TKTCGHTEWV TACRFLSDRR VISGGMDSKL CLWSDVIRGG PARCVDLLGH
TSSISQIEVN ERHGRSIVMS ASYDRTIRIW ELNGAVGGRQ VGCLSGHKGP VTQFSWLDTE
VLSGDRQGTV KVWDVETAQC HLTASSKRGQ IGSLGHLMHP DVGHLVLFGD QGGVLTVVDA
RGPSSAKPLF QDVLHRGGML TFIRTPSLTA VSAPLIVTCG ADQRIVVRDA RRNFSEVCVI
TDHNDFVYSM EVIGNLLLSG AGNGRLLVHH VETGELLYEL RANTAAVREM FASPSMLVTA
GDDGKAKVFD FM
//
