ID A4HIE6_LEIBR Unreviewed; 764 AA.
AC A4HIE6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=LBRM_30_2090 {ECO:0000313|EMBL:CAM40358.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40358.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40358.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40358.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40358.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40358.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799005; CAM40358.1; -; Genomic_DNA.
DR RefSeq; XP_001566836.1; XM_001566786.1.
DR AlphaFoldDB; A4HIE6; -.
DR GeneID; 5417734; -.
DR KEGG; lbz:LBRM_30_2090; -.
DR VEuPathDB; TriTrypDB:LbrM.30.2090; -.
DR VEuPathDB; TriTrypDB:LBRM2903_300027100; -.
DR InParanoid; A4HIE6; -.
DR OMA; MGTYHAG; -.
DR Proteomes; UP000007258; Chromosome 30.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF10; TRIACYLGLYCEROL LIPASE 4-RELATED; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 408..610
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 220..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 82462 MW; 3BDEF9D08A237666 CRC64;
MNTTESYATF VEAAASLDHY CGVEKWAQDA PPLEHCNAVG LLIDATAAQH LIQTNNLPGM
ETFLCSLLKR NAHGLMDASI YRYYHTAPHC LEDYTDNIEF LIKAYAAGTW RGESAVSDCG
ASGERCTPAT STASLLRELR PCWVRLEASA DAQMRSPLLA GTRGPGWTSK QSRSSAALPT
VDVTSKIQLM WQAQLRKTIL TSPALWTAAT AAPSRRHSIS TSLHGLGSNS TSAALPLTDT
STGTARTSAS TLPGEKGTSL IGADVSLVPA TLLQSCVIPK PFYDAMRAGE FASASLPSSP
LVRFEDTATF PAASSLSAGA SKAALPSSVS GSVASVRPSP AVTLAQQLRS SCASLCRFLD
CGASSSTQSQ QHYPHQQRLS VHQSTAASAG HRLQVLRKVL HSYGRTALVL SGGSSMGTYH
AGVARALHEA GVLPDILCGS SAGSIIAAMI CTKSPDELHA FMQSHVLSTE AMHMSPFGED
SGLPGKLRRF FKTGFLMDVR SLMECIRGQC GDMTFLEAYQ LSGKVLNVSV TRSQQEGMPS
DRHVLLNYLT APNVLIWSAV SASCALPGLF TAVQLIEKPS VGAGTFVPYL PGDLWCDGSV
AQDIPRRLLI QLFGVNYLIV SQVNPYVIPF LRPPQSYHIT ETCGSGLARM WFAWVDVCGW
VLTVLFSLHL FPRFGRFEVL FMPFAQFYSG DLTIQPIDSV MKAVPDYLNL VNNPSADYIS
YVASRAQSRT WPLVTRIRLA TSIERCLQRE IHALEAMEYR NQTA
//
