ID A4HIY6_LEIBR Unreviewed; 473 AA.
AC A4HIY6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Bacterial surface antigen (D15) domain-containing protein {ECO:0000259|Pfam:PF01103};
GN ORFNames=LBRM_31_0220 {ECO:0000313|EMBL:CAM42442.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM42442.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM42442.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42442.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM42442.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42442.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
CC -!- SIMILARITY: Belongs to the SAM50/omp85 family.
CC {ECO:0000256|ARBA:ARBA00010913}.
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DR EMBL; FR799006; CAM42442.1; -; Genomic_DNA.
DR RefSeq; XP_001567023.1; XM_001566973.1.
DR AlphaFoldDB; A4HIY6; -.
DR STRING; 5660.A4HIY6; -.
DR GeneID; 5417928; -.
DR KEGG; lbz:LBRM_31_0220; -.
DR VEuPathDB; TriTrypDB:LbrM.31.0220; -.
DR VEuPathDB; TriTrypDB:LBRM2903_310006400; -.
DR InParanoid; A4HIY6; -.
DR OMA; WISMGIF; -.
DR Proteomes; UP000007258; Chromosome 31.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.160.50; membrane protein fhac: a member of the omp85/tpsb transporter family; 1.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR039910; D15-like.
DR PANTHER; PTHR12815:SF18; SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG; 1.
DR PANTHER; PTHR12815; SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF01103; Omp85; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 253..440
FT /note="Bacterial surface antigen (D15)"
FT /evidence="ECO:0000259|Pfam:PF01103"
SQ SEQUENCE 473 AA; 52630 MW; 2F2FFA21FC9E48DB CRC64;
MTEATHQTVN ICEDDLKVAM KMPIRAHVRL VGIEKTHPDV VARDLETIKR CLTIQEAVET
ITEIRSRWIS AGIFRSVQYN FEPTADGNQN DICVRLDVVE EKPKKSIGVF TTDTSIPEIT
VALENILGGR YSVKGNYIPP ATRVHSISFS FLSNVPLIGQ SAEYYIGRKT ENKTYHLANS
ERVEEVKATT TNRKGKLATE FSVGFQRRTL LTKHMKSIPA EDVADFSATD KGYVRHQLTI
TDVAHHANPF LYNMYPLPIY GTQISFCNEF AGGPVGGDFS FLKSEFQGSK YIPLGPFFSM
QLSAKLAGIY PFFGSRIPLN DRLFLSNCHV RGFKSVGPST LDWGGNISRF AATGGNALWA
TSLSLNFPFL FFPNNGIASM HLFANAGHVR MTDSLDALKD AYRWLRDCAC SIGAGIVITR
IPIFGIAPSG RFELNMSIPL GIDKQGNVVC RNGRKSLFDR FRFGLVWSSN FSF
//
