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Database: UniProt
Entry: A4HJJ5_LEIBR
LinkDB: A4HJJ5_LEIBR
Original site: A4HJJ5_LEIBR 
ID   A4HJJ5_LEIBR            Unreviewed;       913 AA.
AC   A4HJJ5;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 2.
DT   24-JAN-2024, entry version 64.
DE   RecName: Full=tRNA ligase phosphodiesterase domain-containing protein {ECO:0000259|Pfam:PF08302};
GN   ORFNames=LBRM_31_2390 {ECO:0000313|EMBL:CAM42659.2};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM42659.2, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM42659.2, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42659.2,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM42659.2, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42659.2,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR799006; CAM42659.2; -; Genomic_DNA.
DR   RefSeq; XP_001567232.2; XM_001567182.2.
DR   AlphaFoldDB; A4HJJ5; -.
DR   GeneID; 5418145; -.
DR   KEGG; lbz:LBRM_31_2390; -.
DR   VEuPathDB; TriTrypDB:LbrM.31.2390; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_310033400; -.
DR   InParanoid; A4HJJ5; -.
DR   Proteomes; UP000007258; Chromosome 31.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003972; F:RNA ligase (ATP) activity; IEA:InterPro.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015965; tRNA_lig_PDEase.
DR   PANTHER; PTHR32004; TRNA LIGASE; 1.
DR   PANTHER; PTHR32004:SF1; TRNA LIGASE; 1.
DR   Pfam; PF08302; tRNA_lig_CPD; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT   DOMAIN          830..897
FT                   /note="tRNA ligase phosphodiesterase"
FT                   /evidence="ECO:0000259|Pfam:PF08302"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   913 AA;  101546 MW;  E71FDC03B202A630 CRC64;
     MVDSFRGTPG QGDRGQGRGG RHGCSPSSGL PTAAHRPSGG KQKKERGFRR ERRARSLVIA
     NAFDVSCAHL SQCRKKGSLF LLPLPIAAAQ RRFLVVERSI SGSDDVLYSQ HRDVWECLPR
     GNARVYIKTD SPNGTVGYTL VGAVNGLRKF GDKDSTYGYP DAVQTVIAME TGSSVCGHLS
     AFALPLAKRG ETSVDADTSC DAAEVEDTSH RFWVIGSKDV HIVLDYAVSE ECLHYYSSLG
     CRYSHAIKIS RLWKAMLPGG AELSSANSDA RAAASPTLTP AQARALHDAL HKEMWTSCFE
     VTFSDSTPLM EDSGVNKLRF YAVTLNKRAF KEACTGHPAL SGNKAKERGN GDSLEETADA
     PNKAPQYSRQ DGLCIPVADA EAFYASVGLP FSHYGSSVVY SSPEYVQLVD TIRRSVNSEG
     CVMCGADAGG KVVRLWTEKS HPYVMERITR EAITNHKLTS NELQALLKKK LDHQPPELRD
     YFKDWEMHRM PWLLHFAAWL QMTRRLTPHM QRNELFQQRS RWHSLQKEFQ TAVDSDPKLY
     SECEQYQHDP VEWDSGTQDL DVIKFVGSQG HGKSTLGRAL YALLQKAQYG PCWVNQDELG
     DRKKFLASLR QAAKAGSKVT HLIIDKMNLD AEMNHDYDNL PLSLTVTWFH PDGEKGLHSV
     CVDRVLGRGS CHRSLRVDPN LAPQERQAQM KTIRRLVHRA LKACEMPKDP PELVLELDIT
     TPINDMVRRI WEKLEDNGMH TLPPVTDKDI SEAIDLSHQY ESFLGKLPRH PIYACISIQQ
     QEDVARLLSV VPQEFTAGQV VQRAFHLTTK YFGGVMDPVA FVQLAKLLGQ SVTLTLESVV
     ADPDGVAVTV FRDDAHYPCA NPIPHITISN RKGVPPKYSN DLISPTAYPG DPAKRKVVQV
     PPNCTISGIF EFR
//
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