ID A4HJJ5_LEIBR Unreviewed; 913 AA.
AC A4HJJ5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=tRNA ligase phosphodiesterase domain-containing protein {ECO:0000259|Pfam:PF08302};
GN ORFNames=LBRM_31_2390 {ECO:0000313|EMBL:CAM42659.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM42659.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM42659.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42659.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM42659.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42659.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799006; CAM42659.2; -; Genomic_DNA.
DR RefSeq; XP_001567232.2; XM_001567182.2.
DR AlphaFoldDB; A4HJJ5; -.
DR GeneID; 5418145; -.
DR KEGG; lbz:LBRM_31_2390; -.
DR VEuPathDB; TriTrypDB:LbrM.31.2390; -.
DR VEuPathDB; TriTrypDB:LBRM2903_310033400; -.
DR InParanoid; A4HJJ5; -.
DR Proteomes; UP000007258; Chromosome 31.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003972; F:RNA ligase (ATP) activity; IEA:InterPro.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015965; tRNA_lig_PDEase.
DR PANTHER; PTHR32004; TRNA LIGASE; 1.
DR PANTHER; PTHR32004:SF1; TRNA LIGASE; 1.
DR Pfam; PF08302; tRNA_lig_CPD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 830..897
FT /note="tRNA ligase phosphodiesterase"
FT /evidence="ECO:0000259|Pfam:PF08302"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 101546 MW; E71FDC03B202A630 CRC64;
MVDSFRGTPG QGDRGQGRGG RHGCSPSSGL PTAAHRPSGG KQKKERGFRR ERRARSLVIA
NAFDVSCAHL SQCRKKGSLF LLPLPIAAAQ RRFLVVERSI SGSDDVLYSQ HRDVWECLPR
GNARVYIKTD SPNGTVGYTL VGAVNGLRKF GDKDSTYGYP DAVQTVIAME TGSSVCGHLS
AFALPLAKRG ETSVDADTSC DAAEVEDTSH RFWVIGSKDV HIVLDYAVSE ECLHYYSSLG
CRYSHAIKIS RLWKAMLPGG AELSSANSDA RAAASPTLTP AQARALHDAL HKEMWTSCFE
VTFSDSTPLM EDSGVNKLRF YAVTLNKRAF KEACTGHPAL SGNKAKERGN GDSLEETADA
PNKAPQYSRQ DGLCIPVADA EAFYASVGLP FSHYGSSVVY SSPEYVQLVD TIRRSVNSEG
CVMCGADAGG KVVRLWTEKS HPYVMERITR EAITNHKLTS NELQALLKKK LDHQPPELRD
YFKDWEMHRM PWLLHFAAWL QMTRRLTPHM QRNELFQQRS RWHSLQKEFQ TAVDSDPKLY
SECEQYQHDP VEWDSGTQDL DVIKFVGSQG HGKSTLGRAL YALLQKAQYG PCWVNQDELG
DRKKFLASLR QAAKAGSKVT HLIIDKMNLD AEMNHDYDNL PLSLTVTWFH PDGEKGLHSV
CVDRVLGRGS CHRSLRVDPN LAPQERQAQM KTIRRLVHRA LKACEMPKDP PELVLELDIT
TPINDMVRRI WEKLEDNGMH TLPPVTDKDI SEAIDLSHQY ESFLGKLPRH PIYACISIQQ
QEDVARLLSV VPQEFTAGQV VQRAFHLTTK YFGGVMDPVA FVQLAKLLGQ SVTLTLESVV
ADPDGVAVTV FRDDAHYPCA NPIPHITISN RKGVPPKYSN DLISPTAYPG DPAKRKVVQV
PPNCTISGIF EFR
//