ID A4HK74_LEIBR Unreviewed; 704 AA.
AC A4HK74;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=FAD dependent oxidoreductase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_32_1020 {ECO:0000313|EMBL:CAM42897.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM42897.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM42897.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42897.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM42897.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42897.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; FR799007; CAM42897.1; -; Genomic_DNA.
DR RefSeq; XP_001567459.1; XM_001567409.1.
DR AlphaFoldDB; A4HK74; -.
DR GeneID; 5418383; -.
DR KEGG; lbz:LBRM_32_1020; -.
DR VEuPathDB; TriTrypDB:LbrM.32.1020; -.
DR VEuPathDB; TriTrypDB:LBRM2903_320015600; -.
DR InParanoid; A4HK74; -.
DR OMA; HAYWLGF; -.
DR Proteomes; UP000007258; Chromosome 32.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR42784; PYRANOSE 2-OXIDASE; 1.
DR PANTHER; PTHR42784:SF1; PYRANOSE 2-OXIDASE; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..704
FT /note="FAD dependent oxidoreductase domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002669898"
SQ SEQUENCE 704 AA; 76141 MW; 8CB11A3A011798E3 CRC64;
MFVELAIVVA VLLVCWYRSF RPRSTNQLRP SYQSHRSTAG LCAGDYVVIG GGVAGLAAAA
ELLRRTDETC QIILIESGND PQSASAAALL FEVGRRDRLL SFAPDLVRVP QELLLKGVRP
TFLGGTPDEG YLAQRPWHYF QDEEVLLGTS SSGSGETLSA AKAKANRYRQ LQYAAYPRGV
GLGGTALLDW GIHLNSLWPS TPEAVPDAEK ATFRTAMTCN EALPQWTRLP MRFPDVRNPL
SWAFAEAVKT LKLAAPYLPS VSAPVKRGAV FPCYLYLDED GRRLALPSAV LGDIAADELH
RRLSVLTGYT AVDLDLAAQD GGEAEERGVR VIGVQVRLSR GGAGAVISIP VRKGVVVAAG
ALHSPRLLHR MSRYRAMRML KPPSSTVPVR DALALPLIFS AVQAVSADSL NVRDAKSSAI
WWLTQRGPYL TPLCDTVLSL PLPHIGSQAE LRVVLFPFGG RDAARFKGMG WDIVLGTPLQ
AFTMLLIFHG IDGLEHMMTL DEEAPQPGVA HTRALCSHQA VCSLSEEVHR KVQDGFLAGI
KECRRLTEAE PLASLALKPG IESTDFTLLV PSDASKAVRL AQLSRLPPSK RSARGKAELK
QLLEWSHRVT ATESYMRRYV DTHAYWLGFA SGSSEAFLAS SSSTPCSSRV AGLQNVFVGD
SSAVTTAHWS GVGKRDTLAA GSRSTCMDAA VRAVTELVKI RGQS
//
