ID   A4HL98_LEIBR            Unreviewed;       875 AA.
AC   A4HL98;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   13-SEP-2023, entry version 71.
DE   RecName: Full=BRE1 E3 ubiquitin ligase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LBRM_33_0620 {ECO:0000313|EMBL:CAM40592.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40592.1, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM40592.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40592.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM40592.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40592.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FR799008; CAM40592.1; -; Genomic_DNA.
DR   RefSeq; XP_001567832.1; XM_001567782.1.
DR   AlphaFoldDB; A4HL98; -.
DR   STRING; 5660.A4HL98; -.
DR   GeneID; 5418765; -.
DR   KEGG; lbz:LBRM_33_0620; -.
DR   VEuPathDB; TriTrypDB:LbrM.33.0620; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_330011700; -.
DR   InParanoid; A4HL98; -.
DR   OMA; RMQRIQK; -.
DR   Proteomes; UP000007258; Chromosome 33.
DR   GO; GO:0035082; P:axoneme assembly; IEA:InterPro.
DR   Gene3D; 6.10.250.3110; -; 1.
DR   InterPro; IPR037386; CCDC40.
DR   PANTHER; PTHR16275; COILED-COIL DOMAIN-CONTAINING PROTEIN 40; 1.
DR   PANTHER; PTHR16275:SF8; COILED-COIL DOMAIN-CONTAINING PROTEIN 40; 1.
DR   Pfam; PF08647; BRE1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          30..285
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          314..573
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          606..633
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          674..701
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          760..808
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   875 AA;  101089 MW;  C642DDF640377FE0 CRC64;
     MPSPNESVAY ESDSDVSEMD PESDILAPVQ RRIEEQLRKH LQELSQQIHE TKNELSGVEK
     ERESCGVDLY NAQQHLATLQ KTLEGYHEKH AAIQQQHDDR LRAREELSAA AEGAQKKVDE
     LRKQYTRHHN ELTKLTETLM KVERFNRELK DEVELERRAA HKTEDDITNL EKAKLRQDSL
     ILSMQERIKA LENESATLDE QIDSQREETK RARETLADAT SEMEAIVIEK KQLVQQWRSS
     LIGMQRRQDA VRKTEEALQQ QKNELLVLEN EITGYRRDIR TKQAENAKLT AFMSRIDNEI
     IILETQMDGL LTKKEEATKA YALLEKSIAS TIQERKAQEQ KMKDKVAELS EVEKQIAKHA
     KAIVEMENEV LVHLSKECTL KQESQGALLE IRKIKDSIRA KEQQVTQMEN ELARIRVDTL
     QSKAYNETLA ASLADLEKEL QSRSAMVEKM QVDIRRRNDE IDRKQNQLDQ LNHQYEQILA
     AHNDMQGDHV GPLEATINSL SKAIASKSSE NEALQQEWIR LQTELVNYKN TMNDINEAIL
     DAQTKATILA QKKDRLLANI SEGKQQVANL QNKSNAMHLE MKQVNTLLSH SNGAQRNASD
     DVFFLENDLV RRLEERKREA IQLEKKVDET RQSKSDIVEQ ILSCERDIMF WERKLQVARE
     TEMALDPTIG CAEMEKMKKE ITFMEQRMSQ LQREQKFLIE EMRKMIDHRD AIRTKGKAIQ
     IASQKNKNGA TRVAVEKENT RLFKELNAKR QESRTKEKLI KESMAEMDRI AADVDRTQHE
     IQNLDAQIED LQGQIAAAKK ERTRAEDEKR LRQNHLQRLR DGEAGTYRLL CYPEESATEA
     ARLDEGRLAV ANVMEELSAQ FPDLAPSLQD LMTSI
//