ID A4HMS7_LEIBR Unreviewed; 832 AA.
AC A4HMS7;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=NADPH--hemoprotein reductase {ECO:0000256|ARBA:ARBA00023797};
DE EC=1.6.2.4 {ECO:0000256|ARBA:ARBA00023797};
GN ORFNames=LBRM_34_2490 {ECO:0000313|EMBL:CAM43466.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM43466.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM43466.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43466.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM43466.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43466.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; FR799009; CAM43466.2; -; Genomic_DNA.
DR RefSeq; XP_001568357.2; XM_001568307.2.
DR AlphaFoldDB; A4HMS7; -.
DR STRING; 5660.A4HMS7; -.
DR GeneID; 5419309; -.
DR KEGG; lbz:LBRM_34_2490; -.
DR VEuPathDB; TriTrypDB:LbrM.34.2490; -.
DR VEuPathDB; TriTrypDB:LBRM2903_340032600; -.
DR InParanoid; A4HMS7; -.
DR Proteomes; UP000007258; Chromosome 35.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF17; NADPH--CYTOCHROME P450 REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 79..285
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 394..636
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 832 AA; 91288 MW; D6A53B9338A8E660 CRC64;
MVQKRYLALV GLLVLGATSS VLLRRQRKVQ RERREFAERY VKQIKAAREA HAQCLNGGSA
SQDSGDISDA DLDDESATVK VIYGSESGNA EALAKGFVMT LRDRGVQAAL IDPSRWSYME
DYLYHNKRNV PLFHPIKVTS PNSHTAKKKL CKTPEKAKES SPPLVYIFIV ATAGEGDPTG
NFMALFHEMQ AAVRRATTDK VSTQSSDAAA PAAPFSATAE APFKNIYYAV FGLGDSSYKY
YCRSATDTNT LLKKGGGISV HRVGFGDARN GMQEDVFDEW QEKVMLALEE KCGLEMTTGT
RAPPKPELQF RFLSSAAATT AATTSTTPQA CPCGATAATA APSAPVVTDN AAPNHRALSS
TAIPSSSVEA ESTSAPPLSL PFPPPPMLLE PSLMNPTRIR LVTKTQLTQP RDSDGSSVYC
FCFESEGTGI SYQAGDHLGI FPTSPPDMVA RYAKALSIPA DELETSVELC ETVPSRGILR
NVLPACVPLR VVLQRYVDLC GRPKKSTLRV LAKYCTDLVQ KEAFLDLLRL PAEKEVEETG
ARTSSARKPK KLRTVVDYLE KFPSCCCIPL GHFIEIMPRT QPRYYSIASD RMSHGTKVEI
IVRVLTDGLA SSYLAHRVEE GEEVFAYVCI SAFHLPQRIG ENRPILMIGP GTGAAAMVGL
CYKKEALMRK QPAAQYGPTV FLFGAQYRQT EYFVEEELQR WSMAPAEMRQ WDINHPTSHA
GLAARRSKTH STEPLSNSVI TMVDCAFSRD QAEKIYVTSL IDKHKDLLYG MLTSTSGGGC
LIFLSGDASC MAKDVDRALV ALLQDRGGMT RMAAIEYLRR MESDHRYLKD VY
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