ID   A4HUB3_LEIIN            Unreviewed;       363 AA.
AC   A4HUB3; A0A2K4YMX6; A0A381MB85;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Thymidylate kinase-like protein {ECO:0000313|EMBL:CAM66020.1};
DE            EC=2.7.4.9 {ECO:0000313|EMBL:CAM66020.1};
GN   ORFNames=LINJ_10_0040 {ECO:0000313|EMBL:CAM66020.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66020.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM66020.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66020.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM66020.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66020.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|ARBA:ARBA00009776}.
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DR   EMBL; FR796442; CAM66020.1; -; Genomic_DNA.
DR   RefSeq; XP_001463654.1; XM_001463617.1.
DR   AlphaFoldDB; A4HUB3; -.
DR   SMR; A4HUB3; -.
DR   STRING; 5671.A4HUB3; -.
DR   GeneID; 5067113; -.
DR   KEGG; lif:LINJ_10_0040; -.
DR   VEuPathDB; TriTrypDB:LINF_100005500; -.
DR   eggNOG; KOG3327; Eukaryota.
DR   InParanoid; A4HUB3; -.
DR   OMA; ETHELAY; -.
DR   OrthoDB; 159727at2759; -.
DR   Proteomes; UP000008153; Chromosome 10.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01672; TMPK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR   PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:CAM66020.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW   Transferase {ECO:0000313|EMBL:CAM66020.1}.
FT   DOMAIN          143..318
FT                   /note="Thymidylate kinase-like"
FT                   /evidence="ECO:0000259|Pfam:PF02223"
SQ   SEQUENCE   363 AA;  40033 MW;  B7007E7202C2DCEF CRC64;
     MRAVVFSDVS SAELGEHIRA IASTSYAEVV YVDVSESSEA DLATAWHTRY GGASHAPPAA
     RDELDDLKNT FVCYLTEQKT LEDSDVVYAV FVAEVPTLVL TPSVTLTPLM HTTADGSVSA
     RKAAIESLFS VAPSSSSAEV IVIEGGDGAG KETQTGLLVR RVHAAGDEVH ALDFPNEKGL
     YGGLVRAVLS GRKGSISELN PQLFSFLYSL NRFGCARQLH FWLRRGSSVV LDRYYTANFG
     HQASKLPPEE REAFISDLEF MEVEWLGLPR ATYVLYLDLP PAAALEAMRR DSTRKQLDIH
     ETAGSDYKER VRQTYRWCCE HLPGWHHIEC FDDDGRRLTR EEVHASITSH LRDAGSRAIG
     APS
//