ID A4HWM6_LEIIN Unreviewed; 445 AA.
AC A4HWM6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Putative nucleolar RNA binding protein {ECO:0000313|EMBL:CAM66855.1};
GN ORFNames=LINJ_15_1430 {ECO:0000313|EMBL:CAM66855.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66855.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM66855.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66855.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM66855.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66855.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family.
CC {ECO:0000256|ARBA:ARBA00009211}.
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DR EMBL; FR796447; CAM66855.1; -; Genomic_DNA.
DR RefSeq; XP_001464467.1; XM_001464430.1.
DR AlphaFoldDB; A4HWM6; -.
DR SMR; A4HWM6; -.
DR STRING; 5671.A4HWM6; -.
DR GeneID; 5067861; -.
DR KEGG; lif:LINJ_15_1430; -.
DR VEuPathDB; TriTrypDB:LINF_100007300; -.
DR eggNOG; KOG2572; Eukaryota.
DR InParanoid; A4HWM6; -.
DR OMA; KGKMARI; -.
DR Proteomes; UP000008153; Chromosome 15.
DR GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58; 1.
DR PANTHER; PTHR10894:SF1; NUCLEOLAR PROTEIN 58; 1.
DR Pfam; PF01798; Nop; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 264..381
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 390..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 48907 MW; FD0B45837CD23FB7 CRC64;
MVYALLELPA GVALFKVDGE RRKLKALLHF KSTADALETT AQLVNGELSK PVRKFLKKNY
LEKEVSEELA VADAKLAKAI KEKLAIPCVS GEDTLPTFRA LKQNIDSLLE DVSAEQLNQT
ALGLAHNLNR YKLKFSPDKV DMMVVQAVSL LEDLDKEINK YAMRAREWYG WHFPELGKTV
NDNVAYCKIV LAMKTRFNAR DTDFSDFLEE ETEQRVKEAA MVSMGTEIAE EDIENISRLC
NEVVAASKYR EQLSTYLSSR MQTIAPNLTT MVGEQIGARL IQKAGSLLTL AKYPSSTVQI
LGAEKALFRA LKQRQATPKY GILYNASVVA KAAPAQKGTM SRVLAAKASL SARIDSFGEG
DNTPALEYRS KVENRLKAFE EGITYGKSGN ARGAGAGLEQ RGSYGDSQGN GFKRPRMNTS
GFNSDRGGRG GGGGFKRSRP ENGGY
//
