ID   A4HWX7_LEIIN            Unreviewed;       750 AA.
AC   A4HWX7; A0A2K4YQW4; A0A381ME83;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM66961.1};
GN   ORFNames=LINJ_16_0800 {ECO:0000313|EMBL:CAM66961.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66961.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM66961.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66961.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM66961.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66961.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- FUNCTION: Involved in cellular auxin homeostasis by regulating auxin
CC       metabolism. Regulates intracellular auxin accumulation at the
CC       endoplasmic reticulum and thus auxin availability for nuclear auxin
CC       signaling. {ECO:0000256|ARBA:ARBA00025100}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the auxin efflux carrier (TC 2.A.69.2) family.
CC       {ECO:0000256|ARBA:ARBA00025752}.
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DR   EMBL; FR796448; CAM66961.1; -; Genomic_DNA.
DR   RefSeq; XP_001464568.1; XM_001464531.1.
DR   AlphaFoldDB; A4HWX7; -.
DR   STRING; 5671.A4HWX7; -.
DR   GeneID; 5067967; -.
DR   KEGG; lif:LINJ_16_0800; -.
DR   VEuPathDB; TriTrypDB:LINF_160013500; -.
DR   eggNOG; ENOG502QUIC; Eukaryota.
DR   InParanoid; A4HWX7; -.
DR   OMA; KMLFFQY; -.
DR   OrthoDB; 128122at2759; -.
DR   Proteomes; UP000008153; Chromosome 16.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0080162; P:endoplasmic reticulum to cytosol auxin transport; IEA:InterPro.
DR   InterPro; IPR004776; Mem_transp_PIN-like.
DR   InterPro; IPR045033; PILS1/3/4/5/7.
DR   PANTHER; PTHR31651; TRANSPORTER; 1.
DR   PANTHER; PTHR31651:SF44; TRANSPORTER; 1.
DR   Pfam; PF03547; Mem_trans; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ   SEQUENCE   750 AA;  82231 MW;  53101E7004B67E20 CRC64;
     MDILGVTFIA VSKVIVAVLV GVFTTNLIPS STITLHNFSF LISALLLTSL TLSNTAKSID
     LEVLFRCSIL ILFSLISIAS GLLWGVVLDV LFFRPDPKYS GIPEELRKDV RLDLLYDHVT
     DEGAEAHCSP SSSPTTKEPG TKKKKKKKSV PYVVVVLSEH FREVGVTGSE IVNALEAPDE
     RQEDCAGYRY AAWVGCSTQN GVTLPLSLMS NVASSISFID MAHSAAYIFV FSISYMLYLW
     SACPAFVEAG QKAVKKQRLI REIMLKHKRM MARCDATTQT LSLPVNQVLE SHEDLVEDVE
     VDGCDSEAGQ ASRLECQVNR FTQLYLAASD PSSSSTSCSD STSPLEAGCV ANTDAFSSRA
     DRHAHSATYS FDLITSLQNS FTQTTRSFAR TSGKRGAAEV TFKILGTPAT RSPTAAGERA
     FAMATAVQLP YDWAATGFVR FKYESEVKAI RKKSASEKVQ QLGRASWVLV KKLMTSPPFL
     SVVLGIFIGI VPPVRRLFEH WPLSMVMDAI RLIGEGSIPS SLLLLGANLA GSSSANAAGP
     AEVRLRNAEQ NTEYPLLPEE WQLLGEDLAY ARWYDAQHTD MVFDSHESFS LQTLMQRGRL
     PASMMPGGAS AASAAPMNEG TDEEGDGAKK GTFIDGVQRT LSLKGIRPTF VWGIIIFRML
     ISPTLSFFLL IFLIDKMPFL FGGRGSLDKT LIMVLMVELA APTAINSTLL FNAYKFMTYQ
     WAKMLFFQYI LCILSMVMWA SIGLSYVMSL
//