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Database: UniProt
Entry: A4HXU4
LinkDB: A4HXU4
Original site: A4HXU4 
ID   CISY_LEIIN              Reviewed;         470 AA.
AC   A4HXU4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   16-OCT-2013, entry version 42.
DE   RecName: Full=Probable citrate synthase, mitochondrial;
DE            EC=2.3.3.1;
DE   Flags: Precursor;
GN   ORFNames=LinJ18.0690, LinJ_18_0690;
OS   Leishmania infantum.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H.,
RA   Chillingworth T., Hance Z., Jagels K., Moule S., Ormond D., Rutter S.,
RA   Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B.,
RA   Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D.,
RA   Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O.,
RA   Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + oxaloacetate = citrate +
CC       CoA.
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       isocitrate from oxaloacetate: step 1/2.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells
CC       capable of oxidative metabolism.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
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DR   EMBL; FR796450; CAM67122.1; -; Genomic_DNA.
DR   RefSeq; XP_001464885.1; XM_001464848.1.
DR   ProteinModelPortal; A4HXU4; -.
DR   SMR; A4HXU4; 24-463.
DR   STRING; 5671.LinJ18.0690; -.
DR   GeneID; 5068291; -.
DR   KEGG; lif:LINJ_18_0690; -.
DR   eggNOG; COG0372; -.
DR   HOGENOM; HOG000130831; -.
DR   KO; K01647; -.
DR   OMA; ELIYEDC; -.
DR   ProtClustDB; CLSZ2438192; -.
DR   UniPathway; UPA00223; UER00717.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR002020; Citrate_synthase-like.
DR   InterPro; IPR016141; Citrate_synthase-like_core.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   PANTHER; PTHR11739; PTHR11739; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Mitochondrion; Reference proteome; Transferase;
KW   Transit peptide; Tricarboxylic acid cycle.
FT   TRANSIT       1      ?       Mitochondrion (Potential).
FT   CHAIN         ?    470       Probable citrate synthase, mitochondrial.
FT                                /FTId=PRO_0000291605.
FT   ACT_SITE    297    297       By similarity.
FT   ACT_SITE    351    351       By similarity.
FT   ACT_SITE    406    406       By similarity.
SQ   SEQUENCE   470 AA;  52192 MW;  D38F325BC1A97824 CRC64;
     MRALRCSIIR GVAGLRMASS VLDEMKEQML RRSKEDHKKI GDLRKKHGHE KLCDATIDAV
     YGGMRGITGL VYEPSLLDSA EGIRFRGLTI LECQEMLPKA PGGKEPLPEA MFWLLMTGEV
     PTEEQARGLN AELHRRVDPE AIAAAQKAIA ALPKNAHPMT AFSVGVLALQ TYSKFAAAYA
     AGKSNKKTYW EYALEDSLDM LARTPAVAAM IYNRETKGQV ELAAPSNSDL DWAANFAKML
     GFQDEEFREC MRLYLSVHAD HEGGNVSAHT TTLVASALSD PYLAFSAGLN GLAGPLHGLA
     NQEVLKYLFS MQERVKADGV NVHDEAALEK ALTKYTWELL NSGQVVPGYG HAVLRKVDPR
     YTCQRNFCLR HNFQDDLFKL VNTIYMIMPG ILKEHGKTKN PYPNVDAHSG VLLQHYGLTE
     QNYYTVLFGL SRQMGVLAGV VWDRLQGRPL ERPKSITTEM LAKKYLCNSL
//
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