ID A4I240_LEIIN Unreviewed; 4122 AA.
AC A4I240; A0A2K4YWS1; A0A381MKD4;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM68827.2};
GN ORFNames=LINJ_26_1090 {ECO:0000313|EMBL:CAM68827.2};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM68827.2, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM68827.2, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68827.2,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM68827.2, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68827.2,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the WD repeat DCAF12 family.
CC {ECO:0000256|ARBA:ARBA00038022}.
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DR EMBL; FR796458; CAM68827.2; -; Genomic_DNA.
DR RefSeq; XP_001470451.2; XM_001470414.2.
DR STRING; 5671.A4I240; -.
DR GeneID; 5069823; -.
DR KEGG; lif:LINJ_26_1090; -.
DR VEuPathDB; TriTrypDB:LINF_260016100; -.
DR eggNOG; KOG3602; Eukaryota.
DR InParanoid; A4I240; -.
DR OrthoDB; 3679036at2759; -.
DR Proteomes; UP000008153; Chromosome 26.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR025139; DUF4062.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008858; TROVE_dom.
DR InterPro; IPR037214; TROVE_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19860; DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED; 1.
DR PANTHER; PTHR19860:SF14; TROVE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13271; DUF4062; 1.
DR Pfam; PF05731; TROVE; 2.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF140864; TROVE domain-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50988; TROVE; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 173..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1862..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2237..2260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2346..2377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2439..2463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2598..2635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3236..3301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3438..3478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3827..3854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4057..4122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2440..2456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2603..2621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4122 AA; 437692 MW; 54484996336AE13D CRC64;
MEYFYRTNAA ELTLLKAALV NLVSSCLMRE PPFEAARPGK LPVITAPATR SPTADEDAVD
VAPAPENDGA STVAQMRELV HLISRQDGEF VLKLALYVRH ELHLRRSPSF LVALCAREPN
CIPFLQPYME KIIVLPSDWL AVANFAYFHD CDAAHDYAGT LTYSVKTERE AHATASAAPS
AEKRSTSSTG TRSPEPSAVE ARSGSSVGSQ GANPLASRMG AKARGDRHQG AAARDPTRSY
IPSALRSALV STFAKFSVFS MAKYDNEAAE HRAKRRQIRR DRAAAEVAVV TSSMTDPDES
SAAGTRPSAL PCRARPQTFT FKQLIRMLHI TEPAYIVCCL LGKRYPTNED DFRRMRLHLT
DPTWKNAAPL KTGATSSAKG VHSAKHTYGR AILGGGGGEG EDEDEDADDS HQDNAELPFC
VFDARRAGQR MHLPVPATWE TQLSKEGNTG RVWDALISSD AVPYMALLRN LRNILTRLCS
ASTHKRVLEK LVDEQQVAAS QQLPYRFYSA YLAVRQIDTL LVHLDALRAV TRKARFRKEV
VSERGHGGRG GGGGGRAAVA SKFAAGAVHE TMREAAKRFE RPLVPRSYLR RYVVQYCAAL
DAAINTSARL NVVPMKGTSI VIICVTSALF EPMSAVGGTA TTPASSQRKV DVTALLVAML
MRSCEQCVVL IYCYDEYVVF RENDPDVERT ALQGMYDEDV GSPSSWDTES GSSRGNDFEN
DGAVDGDFEA MSNPLHRATA TTSQKGAPGL MGLVSSLTAR CSSLLERKRE EVGPDGVATS
FVMFADATGA QFPYAFLDEV IERNMRIESL LVFDEGVHRT YANMNRNAPA FGDLPTYLSR
LRRTCSPDLV YVGVNLKASS PPAAEGVGQV PGATVFPVTA SAAGAPAHRK RGQVSEPAAK
SGATAAFQKA EVERRFGHRN DVLLTGFSDS ILRLVAERTG GGPLAVIERA AETYHVSRLS
ARASQAAWEE RVKALKVLAA LREGHQSHIG GGGGSLEALH DPGAFPFNDY LKPPTQSSTA
TAFPMQSSSL PSTARPLVAE AMTAPAVALP FFDSDGKAVS AIGRNWDCSS RSSDRRLQWL
TSRIAGLSSS TGDAETPSKG RTALPSIRRL LAKPSLSESE AATPSASGAK SSVGEAVDPA
PHWGSGEARE SEPAWLAAEG KNVSSVFHPQ PFISILKLFS MSSSKHGDST TASAAGDAAS
AAASATACAA ATTTLTKTAA TKSVARHRLQ GPASHPLSPT ASAVVRRLIT SYRVCRFFIS
STFLDMNNER NAITLDIFPR LRRWAAEAGL KVTLLEVDLR WGIPALATSR NLSTSVCLNE
VSRCSPFFIG IIGARYGTSP PTPLQVVVDE DVDAEDYAWM RELSDPHVSV TELEMRHAIY
NTKRRVGCDE APWSALFFAR DSPHLLSSFG PADTACRAVY EADSATATEA IECLKQRITE
NGCKLVSYQA AYINPAKTLL PSNSGPGSGG APLLAGGSTR SAAMCSGARA MMEDGLGRWA
VRSRHGFGDG TGQAASSASG KTSEADSLGA LVQARITESG EPKRLTSIDV AIDMADFSSK
VFHELQEVIC RVCGVHPVLD DSAAEKQRRQ HADACVTDAH GPEKNAEARR CARSARSAIS
ATRGATTAEA PDMYEMLVVA QSEFARKLSD LYAAPRGLLE QLSSFALNGI LGVTDESDVP
SDAGAERQRG AAPHGTKRQE FVTPIPSSES GYDSCPVRGF SPLPPPQRAQ HVKDSASSGE
GTPCQPLVAR AGVPGGGTSS ILLLEGCDGD GKSSALAALT ALVLEPMRKA SASEATPRFL
FYSTQAEDDS VRGLLLFLAK SLRIFFQLYG EVSVHDTDAV DELLLMLDHA YAAIHRHFET
SSGDAGTATT ARGGRGANGG RSAAGRAAAG AGHAALVVVL DGLDKSSEAA ELVSLLGTIL
HPLATQHIRF VVSACPRSSL ARALRTRTPP AHVLTVPILS EGERAELVRL HLANYGKVLE
ESFTADELKN LLRKSGAGRP SYLISAITHL RLFSTFDTLR EDIRLLPASR AALHEQLFQH
LQARFDPATC RVVLSILLLR QPVGGVLEFN LYRLVSDVAA ASRLVTLLRG ICLDTHHGRL
FIKSSTFVDA VARRFFRFAS DYQCVQERVL LAELCYQPVD VSLDEQEVKI GLRHVTESIR
RSAANPLTRR TFVPERYAPR ELLGVLQGSV QACRLDVTAA LACYLPFLEC LLVSRRMLSQ
LIGLLSSVVS ATTSASSLAP GAPTSTGALH AEDDADAEDS GSVHPLASYR ALALQWRHYR
SDIQRLGYVL EILQKNYHVL LRQPALLRQC VWNTVGSAMC ISAYDAALTA RLQHALNRMT
TTNKSTASCE VQVGPQGEGR RSEDAVPHSP AARSPDMPTF SALSTMWVHW LNARQHGGEG
RLMLTTASTQ SIRCMAMSPD GTEVAVGGDD GILRRMSADE GEQQQLQQSQ LTPKETESAG
GAGVVGRRRV ASMLRHESAV TSVLYVTTRT AGGPTAGTNG TGASATLAAP TGVAQLLVSG
CARGLLYVWS LEDNSLLQRG TGHLRAISGL VCHPLEPLVL CSCSHDSFVM LWGVGTAEAT
PRLCSEVQAA LALRMPKHPA GSAARHQQER LHQRTREEKG NGELCVGGGG AGPAVMRRGT
PGSSNGIRSR QTPLQASLTP FHTERQHHTP VAAVAFHRSG DIFASGSWDG VLVLHDTREL
RTPSPVITPE MKVPCEPTNQ TRLTSRRSRR AKVVWRTRRG PERRQVTFQS TEFALGSSVR
ALSFSNSLAV TCVVGCHNGT VVVVDHASAA VVARWTSLHS APVTRLTASL DGRCMASADE
HGVVRLTHTG ITGSVFATFN GHHGAVTGLC FRPPRAGHGE DVAGGADALQ APPAWLLTAG
EDRTLQAWRV DSSGSGGFKT QTAMSRRRLI AAHCTAVTAV ASSRDGQLIV TGSADGTAIV
FRVPEEIDDD EDIACRGARG AAMGRDYAGT AAWDRPKAVG KKARSDSSKA AGNVQTTLPL
KPAFTLRHDD CRITRICLAL RDTRIVVGVV FGLVYVWSSS PGLNQVEGRL LLRVRVPEHG
LYPVISLNMV ERCSAAAMNG NRGLAEVRKG GIAQQTRGAE TTLPHANPLQ PAHTHTRSSA
ATAAIVASPP TEKEDESSTL VTAVCANGDV AIFKLLGDAA SLVMAADQAR RRQRQQRHQI
RASYCATGLA DGVFPRSNSA SYASSADTLE RSAEDVGVAM ATSASKSLTW VERVESGGEG
GGVAPRAGSA ATASNSTPRV REAGPAASQV GRWRPLPPTT DCTARGRGGA PVAASATPAP
QAVTFEAPRR CRQALDRRAR KLQRLLSRCR ATEVELCSSF RLHLHRHQLH WANAADAEEI
TSVVWLNAQN PHLSLPGDAT DASAAVLADA LDGEHGRLAL VVAQRQLFLL SSNGHESALS
GCLTVRVPSR LPGSASVLKS ASGTMPKKGM AVGAPERGAS GDGTNVEGKV APPEAVEATA
TEEFEVDLGD LLRDDEYFTS SSSAVAVAPP APSAATAVAL RWFAVAVTTS QGEVFLLRVQ
VPHDHGKHID TLGLPTTPFT GSGARPPTAA SHHLNTNILP RTSITLCRRL SFTGSIASQA
AAAEMDGAEG GTSGAALHRV TAAPRATSVE LCTLPHELGT SLDASAASLP LDAAATAMER
VALLAGCTDG STRVWLAATP PLAPHSRRAP PAGIEMDETP ARSRIGGASD VFIGCFYCTN
SVTVVSGLLN CSVQRASGSG VSALVPSSRW IVGDTLGNVY QLQLERDPPG GVAALLSNSR
DMLTAAGGGA RSGKAEVRMT RFPAENIHVE PWARSLQRLI TMMSSAPPAS AAGAMQTPGA
SDSADEGSLT GGRTAASEAV GTLAWPGWSS HSPEDWLAPV DVSSVLPTLL RRAASATGAR
ADATSEWRST NGKPQAAMLS SSVGAAVRTP GTGDSTLQLS TAAPFCSDLV SFPPVEWSCL
PDLPSVQRVS AAVASSATGG AAEDVTVRGS DGPAHLAWLG SFGLSSPPIA LPSFATEPRA
TRSVLERQGV DNDGGEFAAA QSFQVPLRSL LARYRSQGAD TDSGTPASWS GETAAAVKLP
KRGKENPTVH VEEPAVPPPS QLLTQDDRPH HPINADDEDE ED
//
