ID A4I561_LEIIN Unreviewed; 798 AA.
AC A4I561; A0A2K4Z014; A0A381MNW1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 88.
DE SubName: Full=Putative KU80 protein {ECO:0000313|EMBL:CAM69929.1};
GN ORFNames=LINJ_30_0340 {ECO:0000313|EMBL:CAM69929.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69929.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM69929.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69929.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM69929.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69929.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
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DR EMBL; FR796462; CAM69929.1; -; Genomic_DNA.
DR RefSeq; XP_001466880.1; XM_001466843.1.
DR AlphaFoldDB; A4I561; -.
DR STRING; 5671.A4I561; -.
DR GeneID; 5070922; -.
DR KEGG; lif:LINJ_30_0340; -.
DR VEuPathDB; TriTrypDB:LINF_300008400; -.
DR eggNOG; KOG2326; Eukaryota.
DR InParanoid; A4I561; -.
DR OMA; WAMQYVW; -.
DR OrthoDB; 164896at2759; -.
DR Proteomes; UP000008153; Chromosome 30.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ SEQUENCE 798 AA; 85698 MW; 61E51F642EDC2DF8 CRC64;
MSKGAAVLVL DITLPRAAAL AEACDLCDRI LADKMIYAPS DEVAVILAGT EKSRSALYER
SEQARYNHIT VAADLGPATT LTLAPIAATR AGVAVLPDGA TVRQSIAEAY DFIDALQVAV
AVLQVRTSQK RYNRCIYFLT DARHEVRHKE DLLSLIGALQ RDQVALVVIG FDFQALPAPT
DSQGKFNEFT AGEASAWAAL DRKAQNEIIL AALCAELGSP STLVSPAEAL ASLSLPRCRR
IRQQPVLKVA LRIGDVRLAT QLFTLTQEER LPSLRRSTQE GVDVVQTIEY VAVGGVEEQP
CALAKEERVE AFFLGADRIS CSEADRETMR VKGPRALEAI GFVGEAEVEP YLLMGGTRAL
LPLAGDHAGQ RGFNALVDAM ASSRKAMLVR LVRTADAAPS LCVCFARTAG SSAEQRHLVL
APLPFAEDVR ALRFSEYPEL QFSAAEEQLM DELIDGLSVD DSVLAPHDTF NPVLQQYYAT
LRSKLSAMNV SAEKGNAKAT SSEAAVPQLL PTLRGTSTDF FAEGSAVYEA VSAHRAALAS
CASAFPYEDE VDALLPGSRD AGWKGKPWYQ DVATTSSLID PQAVSPPSAS QGSGGAPSTI
AAAIARGVRC GGEADEASAG SHATSDANSI STAPHDTISG GLSFAITSVD PVGSFSMIVH
HPAVTEAQLN KAKDDLSDVI WELLRSSIKD AIYRKCMACI MALRQFCVKQ DDAAYYNDFL
LKLEVVARQC GRDTDFWAPY VVERKDSANV WPITAQECKS AALPDDTAAK AFLQKDRFDP
AIAFDDTTDD DDWLAEIQ
//