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Database: UniProt
Entry: A4I561_LEIIN
LinkDB: A4I561_LEIIN
Original site: A4I561_LEIIN 
ID   A4I561_LEIIN            Unreviewed;       798 AA.
AC   A4I561; A0A2K4Z014; A0A381MNW1;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   24-JAN-2024, entry version 88.
DE   SubName: Full=Putative KU80 protein {ECO:0000313|EMBL:CAM69929.1};
GN   ORFNames=LINJ_30_0340 {ECO:0000313|EMBL:CAM69929.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69929.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM69929.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69929.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM69929.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69929.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ku80 family.
CC       {ECO:0000256|ARBA:ARBA00007726}.
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DR   EMBL; FR796462; CAM69929.1; -; Genomic_DNA.
DR   RefSeq; XP_001466880.1; XM_001466843.1.
DR   AlphaFoldDB; A4I561; -.
DR   STRING; 5671.A4I561; -.
DR   GeneID; 5070922; -.
DR   KEGG; lif:LINJ_30_0340; -.
DR   VEuPathDB; TriTrypDB:LINF_300008400; -.
DR   eggNOG; KOG2326; Eukaryota.
DR   InParanoid; A4I561; -.
DR   OMA; WAMQYVW; -.
DR   OrthoDB; 164896at2759; -.
DR   Proteomes; UP000008153; Chromosome 30.
DR   GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   CDD; cd00873; KU80; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR024193; Ku80.
DR   InterPro; IPR036494; Ku_C_sf.
DR   InterPro; IPR005161; Ku_N.
DR   InterPro; IPR014893; Ku_PK_bind.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR   PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR   Pfam; PF02735; Ku; 1.
DR   Pfam; PF03731; Ku_N; 1.
DR   Pfam; PF08785; Ku_PK_bind; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR   SUPFAM; SSF100939; SPOC domain-like; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ   SEQUENCE   798 AA;  85698 MW;  61E51F642EDC2DF8 CRC64;
     MSKGAAVLVL DITLPRAAAL AEACDLCDRI LADKMIYAPS DEVAVILAGT EKSRSALYER
     SEQARYNHIT VAADLGPATT LTLAPIAATR AGVAVLPDGA TVRQSIAEAY DFIDALQVAV
     AVLQVRTSQK RYNRCIYFLT DARHEVRHKE DLLSLIGALQ RDQVALVVIG FDFQALPAPT
     DSQGKFNEFT AGEASAWAAL DRKAQNEIIL AALCAELGSP STLVSPAEAL ASLSLPRCRR
     IRQQPVLKVA LRIGDVRLAT QLFTLTQEER LPSLRRSTQE GVDVVQTIEY VAVGGVEEQP
     CALAKEERVE AFFLGADRIS CSEADRETMR VKGPRALEAI GFVGEAEVEP YLLMGGTRAL
     LPLAGDHAGQ RGFNALVDAM ASSRKAMLVR LVRTADAAPS LCVCFARTAG SSAEQRHLVL
     APLPFAEDVR ALRFSEYPEL QFSAAEEQLM DELIDGLSVD DSVLAPHDTF NPVLQQYYAT
     LRSKLSAMNV SAEKGNAKAT SSEAAVPQLL PTLRGTSTDF FAEGSAVYEA VSAHRAALAS
     CASAFPYEDE VDALLPGSRD AGWKGKPWYQ DVATTSSLID PQAVSPPSAS QGSGGAPSTI
     AAAIARGVRC GGEADEASAG SHATSDANSI STAPHDTISG GLSFAITSVD PVGSFSMIVH
     HPAVTEAQLN KAKDDLSDVI WELLRSSIKD AIYRKCMACI MALRQFCVKQ DDAAYYNDFL
     LKLEVVARQC GRDTDFWAPY VVERKDSANV WPITAQECKS AALPDDTAAK AFLQKDRFDP
     AIAFDDTTDD DDWLAEIQ
//
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