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Database: UniProt
Entry: A4I7Q8_LEIIN
LinkDB: A4I7Q8_LEIIN
Original site: A4I7Q8_LEIIN 
ID   A4I7Q8_LEIIN            Unreviewed;       893 AA.
AC   A4I7Q8;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   07-JUN-2017, entry version 55.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=LINJ_32_0970 {ECO:0000313|EMBL:CAM70844.1};
OS   Leishmania infantum.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM70844.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM70844.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H.,
RA   Chillingworth T., Hance Z., Jagels K., Moule S., Ormond D., Rutter S.,
RA   Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B.,
RA   Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D.,
RA   Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O.,
RA   Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM70844.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM70844.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural
RT   change between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; FR796464; CAM70844.1; -; Genomic_DNA.
DR   RefSeq; XP_001467777.1; XM_001467740.1.
DR   STRING; 435258.XP_001467777.1; -.
DR   EnsemblProtists; CAM70844; CAM70844; LINJ_32_0970.
DR   GeneDB; LinJ.32.0970:pep; -.
DR   GeneID; 5071836; -.
DR   KEGG; lif:LINJ_32_0970; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; A4I7Q8; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   Proteomes; UP000008153; Chromosome 32.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008153};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    414    437       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    458    476       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    543    562       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    598       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    636    660       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    832    855       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   893 AA;  101095 MW;  CDE3B2D2D18CADD3 CRC64;
     MPWRQEHCSG LWRSEDMIRV NIILQREVLH DTMYEVGMLG RVQFLDMNEG VTAFARPFTE
     ELRRCEELQR KLHFIEESMC KDADLLERYP GDVNMSATVE EMRSSLLRGQ MHMIDDRIES
     TVNELTAMLT SLEGFQHEMN QNQEMSLLYY KYRLLVDTPS DMAASNSTSP HHGAAVSSDA
     FSRLASLFGF IESKLSEELY RLCYRITRGN AIVEISNEPA MFVDVQTGER NVAKTSFVVL
     CASPTMIVRL KKLMIGLGAD VYTLDEVQSR GIELTTSTTA HHVEDTIEGV ERRKRDVLTQ
     WYEEHRLYKT YLKVEKVVLT AMNMCAMSGS TCTASAWVPL RHEQSLRRAL QDAVASANGS
     VESIVTLHAE QKHPPTFFET NRFTESFQGI VDSYGMARYK EVNPGVFTII TFPYLFGIMY
     GDIGHGFLLL FIALFFIGKE KAWRTAQLNE IVAMVFGGRY LLLLMSLFAI YMGVLYNDFF
     GFSLNLFSSG YTWAPISEQK GTTYPTTPNG LPSVKPPHVY AMGLDAAWTE TDNKLEFYNS
     VKMKHAVIVG VAQMFAGLLL SLSNSIYEKN WYKIAFLFVP EFVFLLCTFG YMSILIMVKW
     CRTWENTNKA PSILEIMTNF FLQPGSVPNP LFSGQAGLQV FLLLAAFAMV PFMLLGMPYI
     EMRDYKRWQQ RRQVGGSRRH HGRALRVSVV AIETSDYTDV FLNEPSASLQ HRQANYSGDE
     SAHRNLMSDD DETANIFGDD SMHPFGVSTA NSEEGATATV IERENEKFEH FDVSELIIHY
     VIHTIEYVLS SVSNTASYLR LWALSLAHAQ LSEVFFSFTV AKTLDIDNSS GFVIAIGVLL
     WLGATLGVLV GMEALSAFLH ALRLHWVEFQ NKFYAGDGQT FDPLDLTTLN TAN
//
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