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Database: UniProt
Entry: A4I9L8_LEIIN
LinkDB: A4I9L8_LEIIN
Original site: A4I9L8_LEIIN 
ID   A4I9L8_LEIIN            Unreviewed;      2556 AA.
AC   A4I9L8;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   07-JUN-2017, entry version 66.
DE   SubName: Full=Putative calcium channel protein {ECO:0000313|EMBL:CAM71521.1};
GN   ORFNames=LINJ_34_0500 {ECO:0000313|EMBL:CAM71521.1};
OS   Leishmania infantum.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM71521.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM71521.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H.,
RA   Chillingworth T., Hance Z., Jagels K., Moule S., Ormond D., Rutter S.,
RA   Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B.,
RA   Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D.,
RA   Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O.,
RA   Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM71521.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM71521.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural
RT   change between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR796466; CAM71521.1; -; Genomic_DNA.
DR   RefSeq; XP_001468437.1; XM_001468400.1.
DR   STRING; 435258.XP_001468437.1; -.
DR   EnsemblProtists; CAM71521; CAM71521; LINJ_34_0500.
DR   GeneDB; LinJ.34.0500:pep; -.
DR   GeneID; 5072513; -.
DR   KEGG; lif:LINJ_34_0500; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; A4I9L8; -.
DR   OMA; FWRLICD; -.
DR   Proteomes; UP000008153; Chromosome 34.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008153};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    143    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    179    200       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    274    297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    389    412       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    890    908       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    920    941       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    948    970       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1010   1032       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1089   1114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1590   1612       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1633   1652       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1664   1684       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1729   1752       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1826   1854       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1909   1930       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1942   1960       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1972   1991       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2011   2032       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2044   2064       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2126   2148       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      145    418       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      889   1121       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1590   1851       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1907   2152       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      812    839       {ECO:0000256|SAM:Coils}.
FT   COILED     2427   2452       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2556 AA;  291351 MW;  2D98227421B728F5 CRC64;
     MEIPLARTQP IEKFFVEYNS AAAEREDDGQ PRDDNEVLLM QFAEYTDDDS FFSSSDTVIE
     CDPQRLRSDP LRRRAVVSVH NTLQLRALTN GRVPEDMVWN NVTRTSWLYQ IHNRAIALQH
     SSFFIFPARW TPRVMVYNVM HHWLMEMFIF LMILGYAIFQ ATWSRYTAPP GGMHKPDHII
     WADVFYTCLL GFEIIARLFA SGGILHKRAF FRSPWRWLDT AVLVLSIMEC TWWQDLWNFT
     AWRLIRTIKC LTYVPAPVRM KLLAKSLLRS TNRLIYVTIF LTYFIFFFGL LGLQLFVGTL
     HSRCVNTLTG AVTSQVCRSV ATGQYGFYWG HHCGVFYTCQ ADAFPNPHYD FRSFDDIGHA
     MLSVFQIMTF QGWSELLQET NDGLAMMAFL YYFFTILVCA WIVPSLYLGV FLEKMDKTSR
     LFVLKQLDFF DHMLTEQRQR MSSMVRLNDY VERDENGFVS HYPAYTLQQQ DDKRLTSDDT
     TSGSTDDKNM NAHRIKSHHR AIQATKWTDE QRIQLQLALT RQRDVAEEAE RKRQLQQAAL
     GDLIVEEGGA GKRQGTGRRG ASPAGAASGS ATQTETSPQP TKERSEFALG GRVGAVQHHP
     AAYAIGDSHQ SDLPFAVRQE VQAEQLRFLD PYTNGASTAK NDMYNSAAAL RTSIDQSRTA
     VPGGGAESTT VLHSRPVSNA RPSTRAPSAP STSVMVAREA AGVVPHRRSM SVRGGTLSRA
     SSMNGRGSLS RLHASMTQVP QAPTQQEQTA YVINDPEGGD FDYAKTLGQK INIIRNIAHM
     FTEGYPRIIS QYLWEHRMMQ HRYGLTPLSY TNKYEEEALR RLRQRRAQER REEREELRRS
     GMGHLIDDDE DEDDDSLAEK PWMRQEGLVP GSMSPIRMAR NIRENAPITV FNYIMYSFII
     ANAVFNASRF DTMPDYWETG TFIAGVCFSV LFMLELLIRL LALGPGPFFT DIVILIEATF
     MVTSLFQLGY SRANTTSLFN WVRFLRLFRV IPCRPLRRVS RVLIHGFPDM VYALVFFTLY
     MFMWLLLGMS FFGSRIGWID YNTSDYTTRG AFETFSHAAY AVAQAFSVNR DQWLYLSWSG
     MRVRGGYTVM YFIATVCVAF IFRFFFIAVM TYAWQAQQET EDYYFMSGSS HGRRGRRSRF
     ARLPFFDFSV WRSFKHIHGG FDRRDVAPDE IYFLNEDMAR QLRLVEAKDR YYREHYGQEK
     SEWSDMGEGS QVGGSDMYGP DGALVNGPQY VNIGGRLYRQ PSLPATEMGF SVVGTPQQRG
     QLRFARHHRA VPATTYAAAQ LQRPAGAHDA LPDEVVGSRS LSRHSRRSMA NPLLADRHSL
     SPAHQGTSVG GPSVARVSDS LAEERAKNTN ISLVPRLTKL GNARALVVAG DDEATADYST
     PEGGVSDEDF EHLLLPGPRL RYKSTMDEGR RVFETCLDCN THMQMPLRAP PGVAQRTAEE
     LHAEHCHMAA VRSSQQLVLN ALIGYTRMQA DHEVTPTKRM VEIVLGQAWS CGMLLFDTIE
     NLSCMDLPEQ ERTWDRMLEA LEMQQWLLGL HVGEEQVGRA TLAYILANQQ RQEAQVREKS
     YKNTWEDRVF FVLSPSNPVR RAVSAVVGSM WFEIAVLCVV YAASICLAVY APDEGNRDFG
     GSYNSAKYKV LHILDDIFSI IFAVEMVLKW ISMGVVLPVG RAYFWHRWNI FDFFIVIISL
     VSWGRPDIFL RYLKVMRCFR ILGPLRYWKW GSSSMSHVAR AIWDSIPTLA NVCLLMLMNY
     IVWAIIFVSL FMDKFNYCSN ASIVNGTQCV EEGYTWAPTQ RNFRNFYESL LTTFEISTGA
     EWIDVIYSAV DSRSALLSPL RNQRPYLGLV FIAYYYVSHF IFFTLFISAV IYCYMLAKSA
     TEDATGTTIE HQVWLRMQGM IFRLKPKVQL LPLDTRVSRL VHFLISNRWF EAFMGLILVF
     NMLTMSLEWY QMSSTQKTTL DAFQYIWVVI FTLEVVLRFV AHGLRFFTRR AYCWDLLIVV
     LSYIQIGLST TATNRVPFNV NVLRMLRVGR VLHLVHLVLP FSTHLTLFHE VLKASVPGLI
     SVTFVYMIAV YVFAILGLHF LGYIVPFGGY IDDKYNNFGT FVNALIMVFR LSTLQNWATM
     LRGSLDRGYY CARASKRCGP TDWAPVYYIP IVICFFLLLS TLYMAVVLDK YVAAVRIYSA
     VTRLDELRRF CRLWSKRDPN GTMWLPSAVL PELLEELRLP LGVSDRRNRV EVMQLLREYN
     IPDHNGRVYY YEVLLPLARR VMAIAFLEAA DAHTAGSQAP RDIAWHLSER SLGALPASYG
     TVRPSSVTVA EHYAAALLQA AFRRDRAMRD YYIAKSELWR RGRAVCVERG LPYDNFGFGK
     TPLAGPDPRE EGMRRGFNIP KDATLANSAG GRVYADPVAA RIAAMREAMG SHKRATDQEP
     PTLLPAVYRS AIYPEEKRFG PNAPGAIRRH ERRDEKLERK RAQEEYERQM YERSTRGCPA
     RTAGEQKDNE TVTAEGAGDV DVGLAYSKGT MEPHPAARGN QYNLDPMDVN YQPPLGTSPE
     ELRQEKVDRR LNAAAAAATA SATLGGISPS TTPEQY
//
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