ID   A4IAB8_LEIIN            Unreviewed;       954 AA.
AC   A4IAB8; A0A2K4Z5E9; A0A381MWG3;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=Peroxisomal ATPase PEX1 {ECO:0000256|ARBA:ARBA00034532};
DE   AltName: Full=Peroxin-1 {ECO:0000256|ARBA:ARBA00032509};
GN   ORFNames=LINJ_34_3300 {ECO:0000313|EMBL:CAM71775.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM71775.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM71775.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM71775.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM71775.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM71775.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SIMILARITY: Belongs to the AAA ATPase family.
CC       {ECO:0000256|ARBA:ARBA00006914}.
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DR   EMBL; FR796466; CAM71775.1; -; Genomic_DNA.
DR   RefSeq; XP_001468687.1; XM_001468650.1.
DR   AlphaFoldDB; A4IAB8; -.
DR   SMR; A4IAB8; -.
DR   STRING; 5671.A4IAB8; -.
DR   GeneID; 5072767; -.
DR   KEGG; lif:LINJ_34_3300; -.
DR   VEuPathDB; TriTrypDB:LINF_340042100; -.
DR   eggNOG; KOG0735; Eukaryota.
DR   InParanoid; A4IAB8; -.
DR   OMA; NYTPFDV; -.
DR   OrthoDB; 167563at2759; -.
DR   Proteomes; UP000008153; Chromosome 34.
DR   GO; GO:0005777; C:peroxisome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0007031; P:peroxisome organization; IEA:InterPro.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.10.330.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR029067; CDC48_domain_2-like_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015342; PEX1-N_C-lobe.
DR   PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR   PANTHER; PTHR23077:SF12; PEROXISOME BIOGENESIS FACTOR 1; 1.
DR   Pfam; PF00004; AAA; 2.
DR   Pfam; PF09262; PEX-1N; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF54585; Cdc48 domain 2-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT   DOMAIN          386..525
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          642..778
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   954 AA;  102391 MW;  739563B23B3BC9F7 CRC64;
     MQQSSFEVAV DRSSQHSFVT VSQHYLDTVL RPLYTGRLPL AVPLRITGRS GHDIYVGCLT
     NRPHTRSKFA LVFPLALCYD HGLKEGELVE CVPLPNTPRA TKVLVAPLTV DDSEVVEQNA
     LRVENLLLRQ VQVVFPSMII SVSIFPGVPA KVMVTAIECG DAEEKLRSGC ATMHEGTHFV
     IATRVRQEQT DRGADGAAAP PLWAFVRGRP ARAAADSGAE RNDTAAVRVR RVTADKYHWK
     NGMVLGVLDC ATLATLNREE VTPGFLRAHL KQMTVVVVDN ADGEAAGAAD EEGVCVVDSL
     AQATNLLLTP HGLDLSAPTA GKAGDATRND SAGVVRPVLS SPALLPLSAV ALDAVTQVHG
     RVAEELQQHL VAALHQSSVP RFANLHQNNV LLCGGKGFGK STVVRAVLDT LSDVHTVTLE
     CGKVKSFSAD IARALMECVL CKPAVLVLEN FDSIAPAQQE GHAEAMTAMT RATLEATLTR
     FCYQFSVRPQ GAVVVLATCS SRDAVHETLR SAYCFRRVLT LEALNRASRT VLTEQLFPYA
     PREDVAAAAA LMDNYTPFDV KQLAARMRAK LAAEPALSLR ECAAACVTFF TPLAHTGINF
     LKGDKVSWES IGGLEEAKTT LYNTLVLPIK HPQLFARLPL KTRSGILLYG PSGCGKTFIV
     ESLVNAENLH CIVINGPEVF GKYIGQSEQK IRDVFERAQA AAPCVVFFDE FDSVAPQRGA
     DDSGVTDRVV NQLLCYLDGV EGRKDVFVVA ASSRPDLIDA ALLRPGRLDK AVVCPVPSED
     DRVAILRSLL SKASAHFSDE ELRQVARRTV NWTPADLSAM VSSASTLMSM RFVERLTKQA
     AGVSGSIAGC GTAPDDEDGF VIAGLGHGVT REKVGDTLKP LCLATHGGAE AAVSDTAALA
     AELMSIDDLW ASVATTRPSL SEKDIQKHER IHALFSKGKS APPPKPPGSR LVTR
//