ID   A4IAC8_LEIIN            Unreviewed;       570 AA.
AC   A4IAC8; A0A2K4Z5F7; A0A381MWH2;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM71785.1};
GN   ORFNames=LINJ_34_3400 {ECO:0000313|EMBL:CAM71785.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM71785.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM71785.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM71785.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM71785.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM71785.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR796466; CAM71785.1; -; Genomic_DNA.
DR   RefSeq; XP_001468697.1; XM_001468660.1.
DR   AlphaFoldDB; A4IAC8; -.
DR   GeneID; 5072777; -.
DR   KEGG; lif:LINJ_34_3400; -.
DR   VEuPathDB; TriTrypDB:LINF_340043600; -.
DR   eggNOG; KOG2214; Eukaryota.
DR   InParanoid; A4IAC8; -.
DR   OMA; CSWFTRG; -.
DR   OrthoDB; 154387at2759; -.
DR   Proteomes; UP000008153; Chromosome 34.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF10; TRIACYLGLYCEROL LIPASE 4-RELATED; 1.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ   SEQUENCE   570 AA;  63276 MW;  07CEEE47261D47E0 CRC64;
     MDSALHAFRM HGASFYHWTS YVVYVIYSCL FFACEVIAGV LEIPTDAPQY DALTHQANCA
     TTYEEWLPIA STLDDMDGFQ KWRTDEASTY FSFEGVMRTI EELLELRSVG SAEALLDNLQ
     KHVHRSLYGI SHRRLYLYKT GTKTVIHSYN SLVCFLLGRV GEAARADRRM AVRTREVLSE
     MSRVYGSTAL LLQGGVLASS AHFGVAKALY DAGLLPPVVY GSGSGALVAT LVCCSTDLAS
     LFHSSSGSNS IAEANALLGT PTADSRWKRF HRLLHTGEVC DPVALADFLQ RSIGDVTFAE
     AFARTGRVLN IPFVSASPVM PRRNADVDVQ LLNYLTSPDV LVRSAVLCAI CPTAAVHPAS
     SSSYGPAGGA APPTRTLLAR TRLTSAIVAY EPPVVHQSYA CSWGDHVGYG VLDPVQRMRG
     LFCIRFCVVS DASVRGYLWQ LLHQSVYRDG LRHRTRMWDW ARYTFALCVL GLAHVFLRLL
     AWMGYDAIAA PSPTSMWTFF EDDVGENMRM HPISSVWSYL RLCYSPTTAN MQVLVLEGER
     QVWPRLEQLR MSISVEQVLA AMLKRLPTYR
//