ID   A4IE45_LEIIN            Unreviewed;      1231 AA.
AC   A4IE45; A0A2K4Z8J7; A0A381MZI3;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   24-JAN-2024, entry version 84.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM73135.1};
GN   ORFNames=LINJ_36_4500 {ECO:0000313|EMBL:CAM73135.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM73135.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM73135.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM73135.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM73135.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM73135.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR796468; CAM73135.1; -; Genomic_DNA.
DR   RefSeq; XP_001470014.1; XM_001469977.1.
DR   AlphaFoldDB; A4IE45; -.
DR   SMR; A4IE45; -.
DR   STRING; 5671.A4IE45; -.
DR   GeneID; 5074126; -.
DR   KEGG; lif:LINJ_36_4500; -.
DR   VEuPathDB; TriTrypDB:LINF_360052200; -.
DR   eggNOG; ENOG502SKD9; Eukaryota.
DR   InParanoid; A4IE45; -.
DR   OMA; YKKRFWV; -.
DR   OrthoDB; 123866at2759; -.
DR   Proteomes; UP000008153; Chromosome 36.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR46090; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B; 1.
DR   PANTHER; PTHR46090:SF2; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B; 1.
DR   Pfam; PF00025; Arf; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ   SEQUENCE   1231 AA;  136667 MW;  DB9B7793BCB41278 CRC64;
     MERTVSELVS QHGPTPHMGL LRCQMERRGR HSLKGYKKRF WVVDERNGWL EVYKNDQEHV
     PIEVFRAADI RNVIYSDDKQ NRFFMMLVQT RGPRDIKFRM GSFEERESWS KAITHIMDVY
     SAINKHKNVL GMVLRRAKTV SEALGVNISI DSGRLLAEVP EDLLQYVAEA VDIALVSVTA
     IVRSFKEEGA DMPRSYILYV HAITEEQSPY QRKETKYSPE GRTMTMNVCL LRVKSERVSF
     VVTQPEEVFR LVQSSVFRNP VIEGWIESEP NCARACAAIQ DYLELPAGRS SWITFQWGQH
     VSDSAKVEAF LQRFVTATFF ERALQSVRDA VVRVERLIAD TNAQTTAKSF TGGSPAAPAR
     DGGCSSPFSE RRQMTTPGVT VQPDSIVFSN SSLAATSATG GFGGAAGGGF HTHQPATPPL
     ANNAAGGGPD AALAIRFIRE NVAGLCIQLD KRVVEKGTAP PPIVTLHASE YEQHCRPAFL
     LVAKCHRVLP RKHHVTKDVL SEELYEVAYN AFLQQQLSLL RTELNGIFHK QVKVVIMWDL
     LFRAAAGLKT PVSAEELPHL LRYVKDVCLS RLQHVAQVLR HARSDVPGHV EDHSYLYKAF
     CSCVGTVVVN FLPYTVSSDA NVFEPNLQAG VLTDTLYCTK EESMPSLMAA LGHAHRGSAS
     KTTRVSLMGA GFHGVLLYAA EAKLGAWCES YFSNPENATP DPRRQLVEDE FDSDTDGTSV
     GMLQDPDFGE AVAYERSAEI RPLTMQRVVN AIYDSQRHAP VDLKIGSEDI MRAIHAFVSA
     FGDDKRPSKH DVARVLIINL QRLRQMYVRA VDDETTSLLT FEQARQLLRD FCEYQTNEQY
     IDVALREVPR LGTEPASPQE EQEGSQRESH EPVRTVKEEM DADVSDSGHP LEENNAYPRS
     PRPRAMNEAS LSVVSNGTAN GAEVTRRGNR RCSLSRRRLQ SNSKRASAIV ASRTAESPSA
     RSALVTPGAM SDRSEPHIRV PSTTSDAFDF ASVTDVALTV LLPREARLAR LAWRVGFVFG
     LENTGKSLII NSMRGIARPT VATVGLSQQV VAFDEWVWAL NELGGRESFR KNWRYYALRI
     DTVHFLMFVL DVLNGQALGE ARQYLKEVTN HYHEVPLLVI FNNFREGHRR FDIREFEALI
     HLDKLRRRHG ADVLSCVCDI TVVHSKNRQL PRTLSSTLRT LSSLLKARSK SENGGDGGAP
     PVPKATTTFS ASVVGGAAGA AAAGAGVGHS T
//