ID A4IFH8_BOVIN Unreviewed; 759 AA.
AC A4IFH8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A3 {ECO:0000313|EMBL:AAI34587.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI34587.1};
RN [1] {ECO:0000313|EMBL:AAI34587.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI34587.1};
RC TISSUE=Ileum {ECO:0000313|EMBL:AAI34587.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC role in the chloride and bicarbonate homeostasis during sperm
CC epididymal maturation and capacitation.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR EMBL; BC134586; AAI34587.1; -; mRNA.
DR RefSeq; NP_001077145.1; NM_001083676.1.
DR AlphaFoldDB; A4IFH8; -.
DR GeneID; 512856; -.
DR KEGG; bta:512856; -.
DR CTD; 1811; -.
DR OrthoDB; 1067648at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 104..121
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 197..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 254..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 283..302
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 370..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 407..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 464..495
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 519..714
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 759 AA; 84344 MW; 75977FDEEB5AC500 CRC64;
MIEPIGNQYV VARPVYSANA FGEDHKKKQR HHKTLLDHLK KLCRCSAQRA KKIAFSSFPI
ASWLPAYRIK EWLLSDIVSG ISTGLVAVLQ GLAFALLVTI PPGYGLYAAF FPVIIYFFLG
TSRHISVGPF PVLSMMVGAV VVRLTPTDSA ADSTFANSSM TNDSSIDEQK VIVAATVTIL
SGIIQLLMGV LRLGFVVIYL SESLISGFTT AAAIHVLVSQ LKFMFQLTVP AHTDPFSLFK
VLESVFSQIE KTNIADLVTS LVILVVVFVV KEINQRYKAK LPVPIPIELI VTVIATGVSY
GFDFKRRFNV AVIGEMKPGF QAPIIPSRQT FQDTIGDCFG IAIVGFAVAF SVASVYSLKY
DYPIDGNQEL IAMGAGNIFG GSFRGFAAST SLSRSGVQES TGGKTQIAGL ISAIIVLIVV
AIGFLLEPLQ KSVLAALALG NLKGMLMQFV EIRRLWRKDK YDCLIWVMTF IFAVVLGLGL
GLAASVAFQL LTIVFRTQFP KCSMLANVGR SNIYKNRKDY SEIYKPEGVK IFRCPSPIYF
ANISFFKQKL IDAIGFRPLR ILRKRNKALK KIRKLQKKGL LQVTPKGFIC TVDGFKDSDE
ELDNDKIEEL DQPINTKDLP FQIDWNANLP LNIVVPKINL HSLILDFSAV SFLDVSSMRG
LKTILQEFIR IQVDVYIVGT DDDFIEKLKR CEFFDDEVKD SIFFLTIHDA VLHILMKKDY
STSKFNPSQE VEAKLDDFTI NTNGGLRNRE CQVPIETKF
//
