ID EGR1_XENTR Reviewed; 498 AA.
AC A4II20; Q6F2L9;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 03-APR-2013, entry version 41.
DE RecName: Full=Early growth response protein 1;
DE Short=EGR-1;
GN Name=egr1; Synonyms=egr;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT "Sequence of Xenopus tropicalis development genes.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the
CC DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the
CC transcription of target genes whose products are required for
CC mitogenesis and differentiation (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
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DR EMBL; AC146894; AAT71995.1; -; Genomic_DNA.
DR EMBL; BC135806; AAI35807.1; -; mRNA.
DR RefSeq; NP_001090830.1; NM_001097361.1.
DR UniGene; Str.67770; -.
DR ProteinModelPortal; A4II20; -.
DR SMR; A4II20; 304-390.
DR STRING; 8364.ENSXETP00000047681; -.
DR Ensembl; ENSXETT00000047681; ENSXETP00000047681; ENSXETG00000006697.
DR GeneID; 100038164; -.
DR KEGG; xtr:100038164; -.
DR CTD; 1958; -.
DR Xenbase; XB-GENE-853412; egr1.
DR eggNOG; COG5048; -.
DR GeneTree; ENSGT00550000074455; -.
DR HOGENOM; HOG000036856; -.
DR InParanoid; Q6F2L9; -.
DR KO; K09203; -.
DR OMA; GEEHEND; -.
DR OrthoDB; EOG4BP1BT; -.
DR Bgee; A4II20; -.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0043010; P:camera-type eye development; IEA:Compara.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 3.
DR InterPro; IPR021839; DUF3432.
DR InterPro; IPR021849; DUF3446.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF11914; DUF3432; 1.
DR Pfam; PF11928; DUF3446; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 498 Early growth response protein 1.
FT /FTId=PRO_0000386429.
FT ZN_FING 307 331 C2H2-type 1.
FT ZN_FING 337 359 C2H2-type 2.
FT ZN_FING 365 387 C2H2-type 3.
FT COMPBIAS 139 183 Ser-rich.
FT COMPBIAS 402 491 Ser-rich.
FT CONFLICT 148 148 P -> PS (in Ref. 2; AAI35807).
SQ SEQUENCE 498 AA; 53997 MW; F0A812624C004C74 CRC64;
MAAAKTDMLV SPLQISDPFS SFPHSPTMDN YPKLEEMMLL NPGAPQFLGA AVPEGSGFNS
PVEGSEQFDH LAADAFSDMS LSGEKAVIES SYANQSARLP SLTYTGRFSL EPAPNSSNTL
WPEPLFSLVS GLVGMANASP SSAPSSSPSS SSSSSQSPPL SCSVQSNDSS PIYSAAPTFP
NSSPELFPDQ SPQPFQNAST ASIPYPPPAY PVSKTTFQVP MIPDYLFPQQ QGDVSLVSAD
QKPFQAMESR TQQPSLTPLS TIKAFATQTS QDLKTINSTY QSQIIKPSRM RKYPNRPSKT
PPHERPYACP VESCDRRFSR SDELTRHIRI HTGQKPFQCR ICMRNFSRSD HLTTHIRTHT
GEKPFACDIC GRKFARSDER KRHTKIHLRQ KDKKADKATP VSVASPVSSY SPSASTSYPS
PVPTSYSSPV SSAYPSPVHS SFPSPTTAVT YPSVTSTFQT HGITSFPSSI VTNSFSSPVS
SALSDMSITY SPRTIEIC
//
