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Database: UniProt
Entry: A4II20
LinkDB: A4II20
Original site: A4II20 
ID   EGR1_XENTR              Reviewed;         498 AA.
AC   A4II20; Q6F2L9;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   29-OCT-2014, entry version 49.
DE   RecName: Full=Early growth response protein 1 {ECO:0000250|UniProtKB:P08046};
DE            Short=EGR-1 {ECO:0000250|UniProtKB:P08046};
GN   Name=egr1 {ECO:0000312|EMBL:AAI35807.1};
GN   Synonyms=egr {ECO:0000303|Ref.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAT71995.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT   "Sequence of Xenopus tropicalis development genes.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAT71995.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole {ECO:0000312|EMBL:AAI35807.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the
CC       DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the
CC       transcription of target genes whose products are required for
CC       mitogenesis and differentiation (By similarity).
CC       {ECO:0000250|UniProtKB:P08046}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P08046}.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
CC       family. {ECO:0000255}.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
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DR   EMBL; AC146894; AAT71995.1; -; Genomic_DNA.
DR   EMBL; BC135806; AAI35807.1; -; mRNA.
DR   RefSeq; NP_001090830.1; NM_001097361.1.
DR   UniGene; Str.39717; -.
DR   ProteinModelPortal; A4II20; -.
DR   SMR; A4II20; 304-390.
DR   STRING; 8364.ENSXETP00000047681; -.
DR   Ensembl; ENSXETT00000047681; ENSXETP00000047681; ENSXETG00000006697.
DR   GeneID; 100038164; -.
DR   KEGG; xtr:100038164; -.
DR   CTD; 1958; -.
DR   Xenbase; XB-GENE-853412; egr1.
DR   eggNOG; COG5048; -.
DR   GeneTree; ENSGT00550000074455; -.
DR   HOGENOM; HOG000036856; -.
DR   InParanoid; A4II20; -.
DR   KO; K09203; -.
DR   OMA; PICILLE; -.
DR   OrthoDB; EOG7Z69C7; -.
DR   TreeFam; TF318980; -.
DR   Bgee; A4II20; -.
DR   ExpressionAtlas; A4II20; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IBA:RefGenome.
DR   GO; GO:0071371; P:cellular response to gonadotropin stimulus; IBA:RefGenome.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:RefGenome.
DR   GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IBA:RefGenome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:RefGenome.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 3.
DR   InterPro; IPR021839; DUF3432.
DR   InterPro; IPR021849; DUF3446.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF11914; DUF3432; 1.
DR   Pfam; PF11928; DUF3446; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    498       Early growth response protein 1.
FT                                /FTId=PRO_0000386429.
FT   ZN_FING     307    331       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     337    359       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     365    387       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS    139    183       Ser-rich. {ECO:0000255}.
FT   COMPBIAS    402    491       Ser-rich. {ECO:0000255}.
FT   CONFLICT    148    148       P -> PS (in Ref. 2; AAI35807).
FT                                {ECO:0000305}.
SQ   SEQUENCE   498 AA;  53997 MW;  F0A812624C004C74 CRC64;
     MAAAKTDMLV SPLQISDPFS SFPHSPTMDN YPKLEEMMLL NPGAPQFLGA AVPEGSGFNS
     PVEGSEQFDH LAADAFSDMS LSGEKAVIES SYANQSARLP SLTYTGRFSL EPAPNSSNTL
     WPEPLFSLVS GLVGMANASP SSAPSSSPSS SSSSSQSPPL SCSVQSNDSS PIYSAAPTFP
     NSSPELFPDQ SPQPFQNAST ASIPYPPPAY PVSKTTFQVP MIPDYLFPQQ QGDVSLVSAD
     QKPFQAMESR TQQPSLTPLS TIKAFATQTS QDLKTINSTY QSQIIKPSRM RKYPNRPSKT
     PPHERPYACP VESCDRRFSR SDELTRHIRI HTGQKPFQCR ICMRNFSRSD HLTTHIRTHT
     GEKPFACDIC GRKFARSDER KRHTKIHLRQ KDKKADKATP VSVASPVSSY SPSASTSYPS
     PVPTSYSSPV SSAYPSPVHS SFPSPTTAVT YPSVTSTFQT HGITSFPSSI VTNSFSSPVS
     SALSDMSITY SPRTIEIC
//
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