ID   UVRC_FRATW              Reviewed;         612 AA.
AC   A4IZ40;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   29-MAY-2013, entry version 46.
DE   RecName: Full=UvrABC system protein C;
DE            Short=Protein UvrC;
DE   AltName: Full=Excinuclease ABC subunit C;
GN   Name=uvrC; OrderedLocusNames=FTW_1461;
OS   Francisella tularensis subsp. tularensis (strain WY96-3418).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=418136;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WY96-3418;
RX   PubMed=17895988; DOI=10.1371/journal.pone.0000947;
RA   Beckstrom-Sternberg S.M., Auerbach R.K., Godbole S., Pearson J.V.,
RA   Beckstrom-Sternberg J.S., Deng Z., Munk C., Kubota K., Zhou Y.,
RA   Bruce D., Noronha J., Scheuermann R.H., Wang A., Wei X., Wang J.,
RA   Hao J., Wagner D.M., Brettin T.S., Brown N., Gilna P., Keim P.S.;
RT   "Complete genomic characterization of a pathogenic A.II strain of
RT   Francisella tularensis subspecies tularensis.";
RL   PLoS ONE 2:E947-E947(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC       of the lesion. The N-terminal half is responsible for the 3'
CC       incision and the C-terminal half is responsible for the 5'
CC       incision (By similarity).
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the UvrC family.
CC   -!- SIMILARITY: Contains 1 GIY-YIG domain.
CC   -!- SIMILARITY: Contains 1 UVR domain.
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DR   EMBL; CP000608; ABO47191.1; -; Genomic_DNA.
DR   RefSeq; YP_001122312.1; NC_009257.1.
DR   ProteinModelPortal; A4IZ40; -.
DR   SMR; A4IZ40; 558-612.
DR   STRING; 418136.FTW_1461; -.
DR   EnsemblBacteria; ABO47191; ABO47191; FTW_1461.
DR   GeneID; 4959947; -.
DR   KEGG; ftw:FTW_1461; -.
DR   PATRIC; 17970392; VBIFraTul58433_1503.
DR   eggNOG; COG0322; -.
DR   HOGENOM; HOG000279961; -.
DR   KO; K03703; -.
DR   OMA; QKLFPIR; -.
DR   ProtClustDB; PRK00558; -.
DR   BioCyc; FTUL418136:GHXJ-1354-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:HAMAP.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1; -.
DR   InterPro; IPR027299; GIY-YIG_dom.
DR   InterPro; IPR000305; GIY-YIG_SF.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF47781; RuvA_2_like; 1.
DR   SUPFAM; SSF46600; UvrB_C; 1.
DR   SUPFAM; SSF82771; UvrC_N; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; SOS response.
FT   CHAIN         1    612       UvrABC system protein C.
FT                                /FTId=PRO_1000077790.
FT   DOMAIN       20     98       GIY-YIG.
FT   DOMAIN      208    243       UVR.
SQ   SEQUENCE   612 AA;  70306 MW;  9450CF3C09F42878 CRC64;
     MIVDNSKDFD LKSFLANLTT HSGVYRMLDK HGEIIYVGKA KNLKNRVNSY FSKGAKDSKT
     LMMVEQIARI EITITPSDYE AYLLENNLIK QHRPKYNILF KDDKSYPYLV ISRDKFPRVS
     FYRGKSAYKK GQCFGPYVSI SSVKNTLNTI QKIFPIRQCE NSYYKSRVRP CLQYQIKRCL
     APCVGLVSQQ QYDEQLAILK KFLAGKFSSV LEEISAKMYQ ASEDMEYEKA QVYRDQLVVL
     RKLQQQQIVD IQEDKTFDVI GIYMQDSYAS IALLQIQNGD VVADRHWSID AKGQDKTSIM
     HAFLSHFYLG DEIRNIWPKN IILSKVEFAD ITDLMNSISQ KIGQAINWII APAADNLKWL
     KLAEVNARQK LNIYTSSKSQ YQKRLESLKE FLELEKDIKR IECFDISHFQ GEATIASCVV
     YTDDGEDRKS HRRYNIKDIK SGDDYAAIHQ AVSRRVSSGL EADNLPDVMI IDGGKGQIHQ
     AEAVFREYGI QDKVQIVSLG KGVERISGKE KIYKGFDDTE YTLDEHNPGF LLLRQVRDSA
     HDHAIKGQRK KVSANRQSSI IEEIEGVGPK RRKALMMYFG GWQELSRASV DEIAKVKGIS
     KKLAQEIWEC FH
//