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Database: UniProt
Entry: A4JC42
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ID   URE1_BURVG              Reviewed;         568 AA.
AC   A4JC42;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   29-OCT-2014, entry version 54.
DE   RecName: Full=Urease subunit alpha {ECO:0000255|HAMAP-Rule:MF_01953};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01953};
DE   AltName: Full=Urea amidohydrolase subunit alpha {ECO:0000255|HAMAP-Rule:MF_01953};
GN   Name=ureC {ECO:0000255|HAMAP-Rule:MF_01953};
GN   OrderedLocusNames=Bcep1808_0833;
OS   Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia
OS   cepacia (strain R1808)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=269482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G4 / LMG 22486;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Urea + H(2)O = CO(2) + 2 NH(3).
CC       {ECO:0000255|HAMAP-Rule:MF_01953}.
CC   -!- COFACTOR: Binds 2 nickel ions per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01953}.
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3)
CC       from urea (urease route): step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_01953}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC
CC       (alpha) subunits. Three heterotrimers associate to form the active
CC       enzyme. {ECO:0000255|HAMAP-Rule:MF_01953}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01953}.
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000255|HAMAP-Rule:MF_01953}.
CC   -!- SIMILARITY: Belongs to the urease family. {ECO:0000255|HAMAP-
CC       Rule:MF_01953}.
CC   -!- SIMILARITY: Contains 1 urease domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01953}.
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DR   EMBL; CP000614; ABO53845.1; -; Genomic_DNA.
DR   RefSeq; WP_011883580.1; NC_009256.1.
DR   RefSeq; YP_001118680.1; NC_009256.1.
DR   ProteinModelPortal; A4JC42; -.
DR   SMR; A4JC42; 5-568.
DR   STRING; 269482.Bcep1808_0833; -.
DR   MEROPS; M38.982; -.
DR   EnsemblBacteria; ABO53845; ABO53845; Bcep1808_0833.
DR   GeneID; 4952529; -.
DR   KEGG; bvi:Bcep1808_0833; -.
DR   PATRIC; 19320128; VBIBurVie89221_5053.
DR   eggNOG; COG0804; -.
DR   HOGENOM; HOG000075064; -.
DR   KO; K01428; -.
DR   OMA; MGQSQAT; -.
DR   OrthoDB; EOG6ND0GM; -.
DR   BioCyc; BVIE269482:GJNA-856-MONOMER; -.
DR   UniPathway; UPA00258; UER00370.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51338; SSF51338; 2.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nickel;
KW   Reference proteome.
FT   CHAIN         1    568       Urease subunit alpha.
FT                                /FTId=PRO_1000073701.
FT   DOMAIN      130    568       Urease. {ECO:0000255|HAMAP-
FT                                Rule:MF_01953}.
FT   ACT_SITE    321    321       Proton donor. {ECO:0000255|HAMAP-
FT                                Rule:MF_01953}.
FT   METAL       135    135       Nickel 1; via tele nitrogen.
FT                                {ECO:0000255|HAMAP-Rule:MF_01953}.
FT   METAL       137    137       Nickel 1; via tele nitrogen.
FT                                {ECO:0000255|HAMAP-Rule:MF_01953}.
FT   METAL       218    218       Nickel 1; via carbamate group.
FT                                {ECO:0000255|HAMAP-Rule:MF_01953}.
FT   METAL       218    218       Nickel 2; via carbamate group.
FT                                {ECO:0000255|HAMAP-Rule:MF_01953}.
FT   METAL       247    247       Nickel 2; via pros nitrogen.
FT                                {ECO:0000255|HAMAP-Rule:MF_01953}.
FT   METAL       273    273       Nickel 2; via tele nitrogen.
FT                                {ECO:0000255|HAMAP-Rule:MF_01953}.
FT   METAL       361    361       Nickel 1. {ECO:0000255|HAMAP-
FT                                Rule:MF_01953}.
FT   BINDING     220    220       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01953}.
FT   MOD_RES     218    218       N6-carboxylysine. {ECO:0000255|HAMAP-
FT                                Rule:MF_01953}.
SQ   SEQUENCE   568 AA;  61031 MW;  73EF5C10FCF33794 CRC64;
     MTLRLSRRAY AEMFGPTTGD RVRLADTELL IEIERDYTIY GEEVKFGGGK VIRDGMGQSQ
     RVAADVPDTI ITNAVILDHW GIVKADIAIK HGRIAAIGKA GNPDIQPGVT IAIGAATEVI
     AGEGLIVTAG GIDTHIHFIS PQQIDEALAS GVTTMLGGGT GPATGTNATT CTPGPWHMER
     MLQAADGWPI NLGFLGKGNV SVPQPLVEQI AAGAIGLKLH EDWGTTPAAI DNCLSVADDT
     DTQVAIHTDT LNEGGFVEST VAAFKGRTIH TYHTEGAGGG HAPDILKVCG ESNVLPSSTN
     PTRPYTINTL DEHLDMLMVC HHLDPSIAED LAFAESRIRR ETIAAEDILH DLGALSMLSS
     DSQAMGRVGE VIIRTWQTAH KMKVQRGALP EDNARNDNFR AKRYVAKYTI NPAITHGIAH
     EVGSIEPGKW ADLVLWEPAF FGIKPSMILK GGMIAMAQMG DPNASIPTPQ PVHYREMFAT
     RGGALARTSL TFVSQMAADA GIAERYGLAK WIVPVRNCRN VTKADMIHNA WRPSISVDPE
     TYDVIADGQL LTCEPATVLP MAQRYFLF
//
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