ID   A4JP17_BURVG            Unreviewed;       517 AA.
AC   A4JP17;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ABO58020.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:ABO58020.1};
GN   OrderedLocusNames=Bcep1808_5069 {ECO:0000313|EMBL:ABO58020.1};
OS   Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia
OS   (strain R1808)).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=269482 {ECO:0000313|EMBL:ABO58020.1, ECO:0000313|Proteomes:UP000002287};
RN   [1] {ECO:0000313|Proteomes:UP000002287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G4 / LMG 22486 {ECO:0000313|Proteomes:UP000002287};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia vietnamiensis G4.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; CP000615; ABO58020.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4JP17; -.
DR   KEGG; bvi:Bcep1808_5069; -.
DR   eggNOG; COG1250; Bacteria.
DR   HOGENOM; CLU_009834_2_2_4; -.
DR   Proteomes; UP000002287; Chromosome 2.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR041040; 3HCDH_RFF.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF18321; 3HCDH_RFF; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:ABO58020.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002287}.
FT   DOMAIN          20..197
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          200..297
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          360..429
FT                   /note="3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-
FT                   fold"
FT                   /evidence="ECO:0000259|Pfam:PF18321"
FT   DOMAIN          430..514
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   517 AA;  54124 MW;  812FA6EA49827F5E CRC64;
     MAVSSAHSVN SGALAPSALV GVIGAGAMGA GIAQVAAAAG HTVLLYDLDE AACDKALAGI
     RAQFARLAEK GRLEPAQADA AGSRIRAVRA LAEFAGAALI VEAAAERLDV KREIFATLER
     HVDERCVLAT NTSSISITSI AAGLRAPQRV AGLHFFNPAP LMALVEVVSG LATAAEVAQL
     LYDTAAAWGK RPVMAKSTPG FIVNRVARPY YAEALRVLNE QGGTPASIDA VMRDAGGFRM
     GPFELMDLIG HDVNFAVTES VFRAYFNDPR YTPSLIQQEL VNAGFLGRKS GRGFYSYAPD
     APPPAPEFEA PCVAPADVVL FEQEGPAVAL HARFAERIPN ARQNGAHADE LIAVAGRASI
     ALTDGRTATL RAAQTGVADL VLVDLARDYA RAGLVALTRA LQCSDAAYAD AVGLFQQAGF
     RVVGVGDVPG MVAMRTVAML ANEAADTVNQ GVCSPADLDL AMEKGVNYPC GPLTWADAIG
     IGRVHRVLSH LATSYGEDRY RVSPRIAALH AAGRTFR
//