ID   A4JT73_BURVG            Unreviewed;       500 AA.
AC   A4JT73;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=Microcystinase C {ECO:0000256|PIRNR:PIRNR012702};
DE            Short=MlrC {ECO:0000256|PIRNR:PIRNR012702};
GN   OrderedLocusNames=Bcep1808_6581 {ECO:0000313|EMBL:ABO59476.1};
OS   Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia
OS   (strain R1808)).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=269482 {ECO:0000313|EMBL:ABO59476.1, ECO:0000313|Proteomes:UP000002287};
RN   [1] {ECO:0000313|Proteomes:UP000002287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G4 / LMG 22486 {ECO:0000313|Proteomes:UP000002287};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 3 of Burkholderia vietnamiensis G4.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in peptidolytic degradation of cyclic heptapeptide
CC       hepatotoxin microcystin (MC). {ECO:0000256|PIRNR:PIRNR012702}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRNR:PIRNR012702};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRNR:PIRNR012702};
CC   -!- SIMILARITY: Belongs to the peptidase M81 family.
CC       {ECO:0000256|PIRNR:PIRNR012702}.
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DR   EMBL; CP000616; ABO59476.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4JT73; -.
DR   KEGG; bvi:Bcep1808_6581; -.
DR   eggNOG; COG5476; Bacteria.
DR   HOGENOM; CLU_028172_1_0_4; -.
DR   Proteomes; UP000002287; Chromosome 3.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR009197; MlrC.
DR   InterPro; IPR010799; MlrC_C.
DR   InterPro; IPR015995; MlrC_N.
DR   Pfam; PF07364; DUF1485; 1.
DR   Pfam; PF07171; MlrC_C; 1.
DR   PIRSF; PIRSF012702; UCP012702; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR012702};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR012702};
KW   Metalloprotease {ECO:0000256|PIRNR:PIRNR012702};
KW   Protease {ECO:0000256|PIRNR:PIRNR012702};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002287}.
FT   DOMAIN          2..285
FT                   /note="Microcystin LR degradation protein MlrC N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07364"
FT   DOMAIN          299..478
FT                   /note="Microcystin LR degradation protein MlrC C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07171"
SQ   SEQUENCE   500 AA;  52634 MW;  8BDBEC27436B822E CRC64;
     MKILIARMNH ETNTFSPVPT PLAAFGRNGP DWGDDAYRAN RGMRTAMAAF IDAAERAGAQ
     IVTPVSAAAN PSGPVAADAY AAICDAIVAA APGCDAVMLD LHGAMVAEQS ADGEGDLLAR
     VRAVLPAAPI AVALDLHANV TQKMIDHADV IVSFKTYPHV DMYETGEHAA RLLLDRLHGR
     ARPVLAWRQP PLLTSTLRSA SAEGAMRRAL EAARAAEADG MLAVSVLAGF SLADIPAPCV
     SVVVVGDGDR AAADAVAERI ARQIWDARDA FVYRSAPLAE SVAQAAALAR GADRPVLMLD
     HGDNCMSGGP CDTMDLLEAA LAQGLDGIVS GPLCDPDAVA ALIDAGVGST VTLPIGNRMP
     SHGGARRTPF RATGVVRAIT DGEYVITGPT YTGQRAYMGR AAVLDIGVAT LVVTERTHEP
     WDLGVFESVG IDPRRARFLL LKSRMYCRPV FVPIAAALVE CDSRGLTGSD YALFRYERLA
     RPVYPLDAVD RWDGAGPRSA
//