ID A4N3Z3_HAEIF Unreviewed; 414 AA.
AC A4N3Z3;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=DNA replication initiation factor {ECO:0000313|EMBL:EDJ90980.1};
GN ORFNames=CGSHi22421_02621 {ECO:0000313|EMBL:EDJ90980.1};
OS Haemophilus influenzae R3021.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=375432 {ECO:0000313|EMBL:EDJ90980.1, ECO:0000313|Proteomes:UP000003798};
RN [1] {ECO:0000313|EMBL:EDJ90980.1, ECO:0000313|Proteomes:UP000003798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R3021 {ECO:0000313|EMBL:EDJ90980.1,
RC ECO:0000313|Proteomes:UP000003798};
RX PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA Ehrlich G.D.;
RT "Characterization and modeling of the Haemophilus influenzae core and
RT supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT nontypeable strains.";
RL Genome Biol. 8:R103.1-R103.18(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; AAZE01000006; EDJ90980.1; -; Genomic_DNA.
DR AlphaFoldDB; A4N3Z3; -.
DR Proteomes; UP000003798; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000313|EMBL:EDJ90980.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein biosynthesis {ECO:0000313|EMBL:EDJ90980.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 414 AA; 43568 MW; CC2E9E610FED0D80 CRC64;
MTNQIPPSLA ENQSKLKQSF VGLQMLFVAF GALVLVPLIT GLDSNTALLT AGVGTLLFQF
CTGKQVPIFL ASSFAFIAPI QYGVQTWGIA TTMGGLAFTG LVYFALSTLV KLRGAEALQR
FFPPVVVGPV IIIIGMGLAP IAVDMSLGKN SAYAYNDAVL VSMVTLLTTL SVAVFAKGLM
KLIPIMFGIT VGYILCLFLG LINFQPVIDA PWFSLPKLTT PEFNLEAILY MLPIAIAPAV
EHVGGIMAIS SVTGKDFLKK PGLHRTLLGD GVATAAASLV GGPPNTTYAE VTGAVMLTRN
FNPNIMTWAA VWAIAISFCG KVGAFLSTIP TIVMGGIMML VFGSIAVVGI STLIRGKVDV
TEARNLCIIS VVMTFGIGNM FVDVGNVSLK GISLCAIVAI ILNLVLPKAK NEVE
//
