ID A4RVA4_OSTLU Unreviewed; 802 AA.
AC A4RVA4;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=OSTLU_34455 {ECO:0000313|EMBL:ABO95099.1};
OS Ostreococcus lucimarinus (strain CCE9901).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Bathycoccaceae; Ostreococcus.
OX NCBI_TaxID=436017 {ECO:0000313|EMBL:ABO95099.1, ECO:0000313|Proteomes:UP000001568};
RN [1] {ECO:0000313|EMBL:ABO95099.1, ECO:0000313|Proteomes:UP000001568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCE9901 {ECO:0000313|EMBL:ABO95099.1,
RC ECO:0000313|Proteomes:UP000001568};
RX PubMed=17460045; DOI=10.1073/pnas.0611046104;
RA Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N.,
RA Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R.,
RA Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K.,
RA Manuell A., Tai V., Vallon O., Piganeau G., Jancek S., Heijde M.,
RA Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I.,
RA Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D.,
RA Van de Peer Y., Moreau H., Grigoriev I.V.;
RT "The tiny eukaryote Ostreococcus provides genomic insights into the paradox
RT of plankton speciation.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|ARBA:ARBA00009476, ECO:0000256|RuleBase:RU361221}.
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DR EMBL; CP000583; ABO95099.1; -; Genomic_DNA.
DR RefSeq; XP_001416806.1; XM_001416769.1.
DR AlphaFoldDB; A4RVA4; -.
DR EnsemblPlants; ABO95099; ABO95099; OSTLU_34455.
DR GeneID; 5000728; -.
DR Gramene; ABO95099; ABO95099; OSTLU_34455.
DR KEGG; olu:OSTLU_34455; -.
DR eggNOG; KOG0474; Eukaryota.
DR HOGENOM; CLU_003181_4_1_1; -.
DR OMA; HEPRWFM; -.
DR OrthoDB; 315083at2759; -.
DR Proteomes; UP000001568; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689:SF161; CHLORIDE CHANNEL PROTEIN B; 1.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000001568};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 129..154
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 175..196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 280..304
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 316..337
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 371..394
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 482..504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 513..531
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 543..568
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 575..599
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 733..795
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 84848 MW; CC918A8864764D26 CRC64;
MTSDGAAPTT PNEDELALRE PLVGGATAIE SGYDSDVDVP ADASASVPEA RREEEPTTPA
TPPRRVNFRG FTARTQSLYL GTERTLSTQT TDSGAPEDAV ESLDFADVDS HWARRARGRG
VFSKVSAKWI VAAFIGVGVG TIAFLIDVSV LYAYRGRGKL FEVCRRRVHL ALAMFAYGGV
GVALAAIAGA LTTYVAPRAK GAGVHYVMAM LNGIYIPKAF DASTLWVKAV ATIAAVSSGL
MIGPEGPLVH VGAAIAMQFT HGASSGMADL FQSDLDRSDF ISAGAAAGIA AAFGAPIGGV
LFSLEEASTF WRESTTRRAL FSASIATFVL ALARAVFLEG SAASEHTQMK NPGLLRVGDF
DSTYFLIELP FYAALAGTCG VISGIVTKSI IFVSTNYTPQ RNERRLAQVV LVSLACVVMF
FGVAAAGKCV TETPGEVSRW SEASIRLWCA EGEYADLGSI LLGNKNDVIA WVLGSPAKAH
TLHALLLSFA TTLISLIMAA NLFVPAGLFM PTILWGSLLG RAAAIVVEHS LSPLGDLRVN
PHAYALVGAT AALAGTFRAT ISVVIIVLEG VGKSAFLFPL LIAVAGANLA SRLFGASLYE
EQLVRSKIPF LHAKPPKALL DDSITAFDVC ARDVVAFKAI EKVSAIEEAL AQTTHNGFPI
LSAKGKRVIG VILRKQLLVL LSRRAFVENL VHAPVLNSSA MEEGHDDDSS SIIARLGLTD
VERERRCDLG VFMALSPASI AADARARDAY VLFTRLSLRH LCVVDAATGA IRGIITRHDL
FDAAESVDRS LHHSVSSSSI LL
//
