ID A4S923_OSTLU Unreviewed; 1024 AA.
AC A4S923;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=OSTLU_28050 {ECO:0000313|EMBL:ABP00152.1};
OS Ostreococcus lucimarinus (strain CCE9901).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Bathycoccaceae; Ostreococcus.
OX NCBI_TaxID=436017 {ECO:0000313|EMBL:ABP00152.1, ECO:0000313|Proteomes:UP000001568};
RN [1] {ECO:0000313|EMBL:ABP00152.1, ECO:0000313|Proteomes:UP000001568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCE9901 {ECO:0000313|EMBL:ABP00152.1,
RC ECO:0000313|Proteomes:UP000001568};
RX PubMed=17460045; DOI=10.1073/pnas.0611046104;
RA Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N.,
RA Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R.,
RA Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K.,
RA Manuell A., Tai V., Vallon O., Piganeau G., Jancek S., Heijde M.,
RA Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I.,
RA Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D.,
RA Van de Peer Y., Moreau H., Grigoriev I.V.;
RT "The tiny eukaryote Ostreococcus provides genomic insights into the paradox
RT of plankton speciation.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; CP000596; ABP00152.1; -; Genomic_DNA.
DR RefSeq; XP_001421858.1; XM_001421821.1.
DR AlphaFoldDB; A4S923; -.
DR EnsemblPlants; ABP00152; ABP00152; OSTLU_28050.
DR GeneID; 5006031; -.
DR Gramene; ABP00152; ABP00152; OSTLU_28050.
DR KEGG; olu:OSTLU_28050; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_272672_0_0_1; -.
DR OMA; RAVHIPQ; -.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000001568; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001568};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 783..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 853..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 907..926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..209
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 495..631
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 647..923
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 313..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 115037 MW; C05F6D868F132305 CRC64;
MTTSTTTFTP PAPSTPTTLC DSQNVACVNT DVADAEVLSA FAAYVCAALA VLTAFGIARK
YVPIYTGREH LRSLKTSGCA PPRFDASANR GGAREACSTT YGWIAHVLTV ADSDIVHTAG
LDALVFLRIA QFGTQLFAPL ALVGVLALAP THLSRSYYET TTTSESSAAR ESHVLMRMTI
ANVEPTSSLM WMHVVMFWAF TAYALWLLTA HYRSYEFLRQ VYGTTTGESN PWRAVHIPQT
VLQKFLQQGI NTNREFMTET IEEEEREGGQ TPAARTMPTT MLLEALLGPK RSNGQMSTEQ
KLRRFPRASF IESTRGPSMA TPSRGYHSHF GPLRVTETPR EESSRSVSEI SMASMSDFDE
MSKEHHLDKL TSDSEDVAIR HNWWEGLDIA EEVWSDQLRS GSDGFGSTDA LSAPRQIKVD
IEGRFPCNDA STCDINPVPS IDDRRYVSAV ADEVSEDGSE KEVVVSVLVQ NYCVLMTDVG
GNLPEGAADP WEGVRAVETF FGGLFPDDFL MVIPLQDYRP VDDLLIERDK LKNEIEKQSM
LQSKRHGHRR MRRGSGFRDE ITGLRDRVAI LDHLVVQERT RILQTEPGSS CIVAFKSQYA
AACAAQCRIT SRQRDLFAIE PAPGPDNLNW QSVLLRRRQR EIRSMVIFPL ILTIILIPTG
MFTGVMSSLC VANQFGANHN DGLKWYCSSD SARYLRILVQ GILPPILLTL WETFVVSFGM
MYLVQAQSKY SSLSKTDESF AEYYFLWAFL NVFFGTVSGY AIQRYLNALN TKGPDAMLQL
LGTSLPLTSN FFLLWIVFRG VYLPTQRLIF PHPGVLCMIV NRWLCCLGCN VTARDRTIKY
SPRSVRLGRE VGVFAMVMMI GLVFSTVAPL ITLLCTVFFV FNFVIWRYHV LYVYERSYEA
GGAMWTTFCN LTIYALVIAQ SFLSFVLLSK QAYAGALILW ITVLPVLSKA SHRFRSIASE
LRWSVPLPQA SIAPRAEFNA ETYMHPALKR NSMGWHPEIG KVWRGYPNVT VKETRIFRRR
QRHR
//
