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Database: UniProt
Entry: A4SAH5_OSTLU
LinkDB: A4SAH5_OSTLU
Original site: A4SAH5_OSTLU 
ID   A4SAH5_OSTLU            Unreviewed;       286 AA.
AC   A4SAH5;
DT   15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   15-MAY-2007, sequence version 1.
DT   24-JAN-2024, entry version 94.
DE   RecName: Full=tRNA pseudouridine synthase {ECO:0000256|RuleBase:RU003792};
DE            EC=5.4.99.12 {ECO:0000256|RuleBase:RU003792};
GN   ORFNames=OSTLU_28572 {ECO:0000313|EMBL:ABP00707.1};
OS   Ostreococcus lucimarinus (strain CCE9901).
OC   Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC   Bathycoccaceae; Ostreococcus.
OX   NCBI_TaxID=436017 {ECO:0000313|EMBL:ABP00707.1, ECO:0000313|Proteomes:UP000001568};
RN   [1] {ECO:0000313|EMBL:ABP00707.1, ECO:0000313|Proteomes:UP000001568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCE9901 {ECO:0000313|EMBL:ABP00707.1,
RC   ECO:0000313|Proteomes:UP000001568};
RX   PubMed=17460045; DOI=10.1073/pnas.0611046104;
RA   Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N.,
RA   Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R.,
RA   Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K.,
RA   Manuell A., Tai V., Vallon O., Piganeau G., Jancek S., Heijde M.,
RA   Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I.,
RA   Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D.,
RA   Van de Peer Y., Moreau H., Grigoriev I.V.;
RT   "The tiny eukaryote Ostreococcus provides genomic insights into the paradox
RT   of plankton speciation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA;
CC         Xref=Rhea:RHEA:22376, Rhea:RHEA-COMP:10085, Rhea:RHEA-COMP:10087,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.12;
CC         Evidence={ECO:0000256|RuleBase:RU003792};
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC       {ECO:0000256|ARBA:ARBA00009375, ECO:0000256|RuleBase:RU003792}.
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DR   EMBL; CP000599; ABP00707.1; -; Genomic_DNA.
DR   RefSeq; XP_001422390.1; XM_001422353.1.
DR   AlphaFoldDB; A4SAH5; -.
DR   STRING; 436017.A4SAH5; -.
DR   EnsemblPlants; ABP00707; ABP00707; OSTLU_28572.
DR   GeneID; 5006491; -.
DR   Gramene; ABP00707; ABP00707; OSTLU_28572.
DR   KEGG; olu:OSTLU_28572; -.
DR   eggNOG; KOG4393; Eukaryota.
DR   HOGENOM; CLU_014673_0_1_1; -.
DR   OMA; KGVHANN; -.
DR   OrthoDB; 313775at2759; -.
DR   Proteomes; UP000001568; Chromosome 19.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02570; PseudoU_synth_EcTruA; 1.
DR   Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR   Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR   HAMAP; MF_00171; TruA; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR   NCBIfam; TIGR00071; hisT_truA; 1.
DR   PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11142:SF0; TRNA PSEUDOURIDINE SYNTHASE-LIKE 1; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003792};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001568};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694,
KW   ECO:0000256|RuleBase:RU003792}.
FT   DOMAIN          23..123
FT                   /note="Pseudouridine synthase I TruA alpha/beta"
FT                   /evidence="ECO:0000259|Pfam:PF01416"
FT   DOMAIN          164..273
FT                   /note="Pseudouridine synthase I TruA alpha/beta"
FT                   /evidence="ECO:0000259|Pfam:PF01416"
FT   ACT_SITE        70
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001430-1"
FT   BINDING         130
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001430-2"
SQ   SEQUENCE   286 AA;  32543 MW;  F7CCE4067AFBF3CE CRC64;
     MSDAQLELHR ASGRDVTYAL KISYDGERYN GFQYQGEDVP TIQRELERAL AKLTGIDRER
     LRLGAAGRTD AGVHARGQVA HFYCEKSLGE DLTRCQKAMN GMLPKDIRVD AFWEPHPLFH
     SRFHASGKTY HYYVDARATS SPFTRKYAHQ VGWRPCDVEL LRQAAQLFVG TMDYKGFCNT
     SRDKSNEDRN TTRTIRRFDV FEDAADDGLI RLEVEGDGFL YRQVRNMVGA LLVVASGKHD
     LAYLRTLIET KDRSRAPMGA PARGLFLHEV FYPTEVLARP RSDDTA
//
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