ID A4SJZ0_AERS4 Unreviewed; 481 AA.
AC A4SJZ0;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=ASA_1090 {ECO:0000313|EMBL:ABO89212.1};
OS Aeromonas salmonicida (strain A449).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=382245 {ECO:0000313|EMBL:ABO89212.1, ECO:0000313|Proteomes:UP000000225};
RN [1] {ECO:0000313|Proteomes:UP000000225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A449 {ECO:0000313|Proteomes:UP000000225};
RX PubMed=18801193; DOI=10.1186/1471-2164-9-427;
RA Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J.,
RA Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C.,
RA Brown L.L.;
RT "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into
RT the evolution of a fish pathogen.";
RL BMC Genomics 9:427-427(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP000644; ABO89212.1; -; Genomic_DNA.
DR RefSeq; WP_005317260.1; NC_009348.1.
DR AlphaFoldDB; A4SJZ0; -.
DR STRING; 29491.GCA_000820065_02548; -.
DR KEGG; asa:ASA_1090; -.
DR PATRIC; fig|382245.13.peg.1086; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_89_37_6; -.
DR Proteomes; UP000000225; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.20.5.1040; Sensor protein qsec; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR PANTHER; PTHR45436:SF14; SENSOR PROTEIN QSEC; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ABO89212.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 265..476
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 481 AA; 53862 MW; 12BC5EC2A4083964 CRC64;
MNHPRSIRRF LLSGILALVS TSLAISALIG YLEASHEMEE LFDARLAQSS RITNQLLSRY
LDQHSALPAN GTVYEEWEQH NPDQWQKDTS FNLRGEDREL TPLGHEFERN LYFQLLNEQG
GILLRSPSSP NQPLVELAPG FNTVEKDRHQ WRTFTLYNQN EHTWLVVAER DDERSELASK
MATLAMLPLL ITLPFLLGLL WWLISRGLAP LRLLAQAIGE RHPANLSPLN LKIRAQELTP
LTDEINRLMH ALADTIEREK QFTNEAAHEL RTPLAVLRIH SENALAAEDD ASRQQSLHKM
LLALDRSDRL IRQLLTQARI DSQQGLELTE LDLGNLLQGT LATLAPIALK KGQQLSLEGA
EHLTVMGQST LLDLMFSNLI DNALRYTPAQ GEIAVEVQQE GNRVRVDIRD TGPGIPTAAL
SRLCERFFRV NPQQGDGVGL GMAIVSRIAQ LHGADLDIHN RPEGGLEVSV RLPAPPLRAL
A
//
