ID A4SNL7_AERS4 Unreviewed; 750 AA.
AC A4SNL7;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=ATP-dependent Clp protease, ATP-binding subunit ClpA {ECO:0000313|EMBL:ABO90489.1};
GN Name=clpA {ECO:0000313|EMBL:ABO90489.1};
GN OrderedLocusNames=ASA_2446 {ECO:0000313|EMBL:ABO90489.1};
OS Aeromonas salmonicida (strain A449).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=382245 {ECO:0000313|EMBL:ABO90489.1, ECO:0000313|Proteomes:UP000000225};
RN [1] {ECO:0000313|Proteomes:UP000000225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A449 {ECO:0000313|Proteomes:UP000000225};
RX PubMed=18801193; DOI=10.1186/1471-2164-9-427;
RA Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J.,
RA Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C.,
RA Brown L.L.;
RT "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into
RT the evolution of a fish pathogen.";
RL BMC Genomics 9:427-427(2008).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR EMBL; CP000644; ABO90489.1; -; Genomic_DNA.
DR RefSeq; WP_005310727.1; NC_009348.1.
DR AlphaFoldDB; A4SNL7; -.
DR STRING; 29491.GCA_000820065_01480; -.
DR KEGG; asa:ASA_2446; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_2_6; -.
DR Proteomes; UP000000225; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0043335; P:protein unfolding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR013461; ClpA.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02639; ClpA; 1.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF111; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPA; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Hydrolase {ECO:0000313|EMBL:ABO90489.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:ABO90489.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 1..145
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
SQ SEQUENCE 750 AA; 83151 MW; 9C6060C0EF304AEA CRC64;
MLNKDLEKTL NEAFKLARDE RHEFMTVEHL LLALLDNSSA HEALSSCGAD VELMRKEISA
FIGQTTPLIP RDDEDRETQP TLGFQRVLQR AVFHVQSSGN TEVSGANVLV AIFSEQESQA
AYFLKKAEIS RLDVVNFLSH GVRKDSKPDN SSNNAESDDD VSAAQIESFA TNLNQLVLEG
RIDPLIGRDQ ELSRTIQVLC RRRKNNPLLV GEAGVGKTAI AEGLAYRIVK GDVPEVIAGS
TIYSLDMGSL LAGTKYRGDF EKRLKVLLKQ IERQEGAILF IDEIHTIIGA GAASGGQLDA
ANLIKPLLSN GLLRCVGSTT YQEYSQIFEK DRALARRFQK IDIVEPSVDD TTRILMGLKS
RYESHHGVRY TVKAIRAAVE LSAKYINDRH LPDKAIDVID EAGAGQRLLP VSKRKKVINV
PEIEAIVAKI ARIPEKSVSS SDKEVLKNLE RNLKMVVFGQ DKAIEVLTDA IRLSRSGLGN
ERRPVGCFLF AGPTGVGKTE VTQQLGKALG VEMLRFDMSE YMERHTVSRL IGAPPGYVGF
EQGGLLTDSV LKHPHSVVLL DEIEKAHPDV FNLLLQVMDN GTLTDNNGRK ADFRNVILVM
TTNAGVQETQ RKSIGFQQQD MSHDAMAVIN KTFSPEFRNR LDHTIWFNHL DMQVIHQVVD
KFIVELQVQL DAKGVSLEVS EGVRHWLAEK GYDRAMGARP MGRVIQEHLK KPLANEILFG
SLVDGGVVKV ELVNDSLSFD FQVNIEAVSH
//
