ID GLPK_MYCGI Reviewed; 505 AA.
AC A4T5Y1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 01-MAY-2013, entry version 51.
DE RecName: Full=Glycerol kinase;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase;
DE AltName: Full=Glycerokinase;
DE Short=GK;
GN Name=glpK; OrderedLocusNames=Mflv_1327;
OS Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens
OS (strain ATCC 700033 / PYR-GCK)).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX NCBI_TaxID=350054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PYR-GCK;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.,
RA Richardson P.;
RT "Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC metabolism (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC phosphate.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR EMBL; CP000656; ABP43809.1; -; Genomic_DNA.
DR RefSeq; YP_001132597.1; NC_009338.1.
DR ProteinModelPortal; A4T5Y1; -.
DR SMR; A4T5Y1; 2-503.
DR STRING; 350054.Mflv_1327; -.
DR EnsemblBacteria; ABP43809; ABP43809; Mflv_1327.
DR GeneID; 4972653; -.
DR KEGG; mgi:Mflv_1327; -.
DR PATRIC; 18030696; VBIMycGil17082_1355.
DR eggNOG; COG0554; -.
DR HOGENOM; HOG000222134; -.
DR KO; K00864; -.
DR OMA; PDGGLHV; -.
DR ProtClustDB; PRK00047; -.
DR BioCyc; MGIL350054:GHK8-1724-MONOMER; -.
DR UniPathway; UPA00618; UER00672.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR HAMAP; MF_00186; Glycerol_kin; 1; -.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR PANTHER; PTHR10196:SF9; PTHR10196:SF9; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW Nucleotide-binding; Transferase.
FT CHAIN 1 505 Glycerol kinase.
FT /FTId=PRO_1000077422.
FT NP_BIND 416 420 ATP (By similarity).
FT BINDING 12 12 Substrate (By similarity).
FT BINDING 16 16 ATP (By similarity).
FT BINDING 82 82 Substrate (By similarity).
FT BINDING 134 134 Substrate (By similarity).
FT BINDING 249 249 Substrate (By similarity).
FT BINDING 271 271 ATP (By similarity).
FT BINDING 315 315 ATP; via carbonyl oxygen (By similarity).
SQ SEQUENCE 505 AA; 54768 MW; 906FB1A394DD126A CRC64;
MADFVAAIDQ GTTSTRCMIF DHDGAEVGRH QLEHEQILPK AGWVEHNPVE IWERTGSVLA
TALNATKLAT TDLAALGITN QRETSLVWNR HTGRPYYNAI VWQDTRTDRI ASALDRDGRG
DVIRRKAGLP PATYFSGGKL QWLLENVDGL RADAANGDAL FGTTDTWVLW NLTGGHRGGV
HVTDVTNASR TMLMNLETLD WDDELLGFFD IPRQMLPEIR PSSSPQPYGV TVETGPADGE
IPITGILGDQ QAAMVGQVCL DVGEAKNTYG TGNFLLLNTG EKIVRSDNGL LTTVCYQFGD
SKPVYALEGS IAVTGSAVQW LRDQLGIISG ASQSESLARQ VDDNGGVYFV PAFSGLFAPY
WRSDARGAIV GLSRFNTNAH VARATLEAIC YQSRDVVDAM AADSGVPLEV LKVDGGITAN
DLCMQIQADV LGVDVVKPVV AETTALGAAY AAGLAVGFWE GADDLRANWQ EGRRWSPQWS
DEQRAEGYAG WQKAVHRTLD WVDVE
//
