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Database: UniProt
Entry: A4UIV1_WNV
LinkDB: A4UIV1_WNV
Original site: A4UIV1_WNV 
ID   A4UIV1_WNV              Unreviewed;       668 AA.
AC   A4UIV1;
DT   15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   15-MAY-2007, sequence version 1.
DT   24-JAN-2024, entry version 88.
DE   SubName: Full=Polyprotein {ECO:0000313|EMBL:ABO69592.1};
DE   Flags: Fragment;
OS   West Nile virus (WNV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC   Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus nilense.
OX   NCBI_TaxID=11082 {ECO:0000313|EMBL:ABO69592.1};
OH   NCBI_TaxID=7158; Aedes.
OH   NCBI_TaxID=8495; Alligator.
OH   NCBI_TaxID=34610; Amblyomma variegatum (Tropical bont tick).
OH   NCBI_TaxID=8782; Aves (birds).
OH   NCBI_TaxID=53527; Culex.
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=34627; Hyalomma marginatum.
OH   NCBI_TaxID=308735; Mansonia uniformis.
OH   NCBI_TaxID=308737; Mimomyia.
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
OH   NCBI_TaxID=34630; Rhipicephalus.
OH   NCBI_TaxID=34861; Sciurus niger (Eastern fox squirrel).
RN   [1] {ECO:0000313|EMBL:ABO69592.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M8447 {ECO:0000313|EMBL:ABO69592.1};
RX   PubMed=17553276;
RA   Davis T., Li L., May F.J., Bueno R.Jr., Dennett J.A., Bala A.A., Guzman H.,
RA   Elizonda-Quiroga D., Tesh R.B., Barrett A.D.;
RT   "Genetic stasis of dominant West Nile virus genotype, Houston, Texas.";
RL   Emerg. Infect. Dis. 13:601-604(2007).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Host endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004153}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004385}.
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DR   EMBL; EF205419; ABO69592.1; -; Genomic_RNA.
DR   SMR; A4UIV1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   CDD; cd12149; Flavi_E_C; 1.
DR   CDD; cd17038; Flavi_M; 1.
DR   Gene3D; 1.20.1280.260; -; 1.
DR   Gene3D; 2.60.40.350; -; 1.
DR   Gene3D; 1.10.8.970; Flavivirus envelope glycoprotein M-like; 1.
DR   Gene3D; 2.60.260.50; Flavivirus polyprotein propeptide domain; 1.
DR   Gene3D; 2.60.98.10; Tick-borne Encephalitis virus Glycoprotein, domain 1; 1.
DR   Gene3D; 3.30.67.10; Viral Envelope Glycoprotein, domain 2; 1.
DR   Gene3D; 3.30.387.10; Viral Envelope Glycoprotein, domain 3; 1.
DR   InterPro; IPR000069; Env_glycoprot_M_flavivir.
DR   InterPro; IPR038302; Env_glycoprot_M_sf_flavivir.
DR   InterPro; IPR013755; Flav_gly_cen_dom_subdom1.
DR   InterPro; IPR027287; Flavi_E_Ig-like.
DR   InterPro; IPR026470; Flavi_E_Stem/Anchor_dom.
DR   InterPro; IPR038345; Flavi_E_Stem/Anchor_dom_sf.
DR   InterPro; IPR011998; Flavi_Glycoprot_E_cen/dimer.
DR   InterPro; IPR002535; Flavi_propep.
DR   InterPro; IPR038688; Flavi_propep_sf.
DR   InterPro; IPR000336; Flavivir/Alphavir_Ig-like_sf.
DR   InterPro; IPR036253; Glycoprot_cen/dimer_sf.
DR   InterPro; IPR038055; Glycoprot_E_dimer_dom.
DR   InterPro; IPR013756; GlyE_cen_dom_subdom2.
DR   InterPro; IPR014756; Ig_E-set.
DR   NCBIfam; TIGR04240; flavi_E_stem; 1.
DR   Pfam; PF21659; Flavi_E_stem; 1.
DR   Pfam; PF02832; Flavi_glycop_C; 1.
DR   Pfam; PF00869; Flavi_glycoprot; 1.
DR   Pfam; PF01004; Flavi_M; 1.
DR   Pfam; PF01570; Flavi_propep; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF56983; Viral glycoprotein, central and dimerisation domains; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Fusion of virus membrane with host endosomal membrane
KW   {ECO:0000256|ARBA:ARBA00022510};
KW   Fusion of virus membrane with host membrane
KW   {ECO:0000256|ARBA:ARBA00022506};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW   Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW   Virion {ECO:0000256|ARBA:ARBA00022844};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT   TRANSMEM        127..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        152..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        620..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        647..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          10..91
FT                   /note="Flavivirus polyprotein propeptide"
FT                   /evidence="ECO:0000259|Pfam:PF01570"
FT   DOMAIN          95..167
FT                   /note="Envelope glycoprotein M flavivirus"
FT                   /evidence="ECO:0000259|Pfam:PF01004"
FT   DOMAIN          170..466
FT                   /note="Envelope glycoprotein E central and dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF00869"
FT   DOMAIN          469..566
FT                   /note="Glycoprotein E immunoglobulin-like"
FT                   /evidence="ECO:0000259|Pfam:PF02832"
FT   DOMAIN          569..663
FT                   /note="Flavivirus envelope glycoprotein E Stem/Anchor"
FT                   /evidence="ECO:0000259|Pfam:PF21659"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABO69592.1"
FT   NON_TER         668
FT                   /evidence="ECO:0000313|EMBL:ABO69592.1"
SQ   SEQUENCE   668 AA;  72040 MW;  CE56FA15523403CC CRC64;
     VTLSNFQGKV MMTVNATDVT DVITIPTAAG KNLCIVRAMD VGYMCDDTIT YECPVLSAGN
     DPEDIDCWCT KSAVYVRYGR CTKTRHSRRS RRSLTVQTHG ESTLANKKGA WMDSTKATRY
     LVKTESWILR NPGYALVAAV IGWMLGSNTM QRVVFVVLLL LVAPAYSFNC LGMSNRDFLE
     GVSGATWVDL VLEGDSCVTI MSKDKPTIDV KMMNMEAANL AEVRSYCYLA TVSDLSTKAA
     CPTMGEAHND KRADPAFVCR QGVVDRGWGN GCGLFGKGSI DTCAKFACST KAIGRTILKE
     NIKYEVAIFV HGPTTVESHG NYSTQAGATQ AGRFSITPAA PSYTLKLGEY GEVTVDCEPR
     SGIDTNAYYV MTVGTKTFLV HREWFMDLNL PWSSAGSTVW RNRETLMEFE EPHATKQSVI
     ALGSQEGALH QALAGAIPVE FSSNTVKLTS GHLKCRVKME KLQLKGTTYG VCSKAFKFLG
     TPADTGHGTV VLELQYTGTD GPCKVPISSV ASLNDLTPVG RLVTVNPFVS VATANAKVLI
     ELEPPFGDSY IVVGRGEQQI NHHWHKSGSS IGKAFTTTLK GAQRLAALGD TAWDFGSVGG
     VFTSVGKAVH QVFGGAFRSL FGGMSWITQG LLGALLLWMG INARDRSIAL TFLAVGGVLL
     FLSVNVHA
//
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