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Database: UniProt
Entry: A4VKA4
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Original site: A4VKA4 
ID   FADA_PSEU5              Reviewed;         391 AA.
AC   A4VKA4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   11-JUN-2014, entry version 54.
DE   RecName: Full=3-ketoacyl-CoA thiolase;
DE            EC=2.3.1.16;
DE   AltName: Full=Acetyl-CoA acyltransferase;
DE   AltName: Full=Beta-ketothiolase;
DE   AltName: Full=Fatty acid oxidation complex subunit beta;
GN   Name=fadA; Synonyms=foaB; OrderedLocusNames=PST_1727;
OS   Pseudomonas stutzeri (strain A1501).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=379731;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A1501;
RA   Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W.,
RA   Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D.,
RA   Lin Z., Wang Y., Elmerich C., Lin M., Jin Q.;
RT   "Complete genome sequence of the metabolically versatile and root-
RT   associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the final step of fatty acid oxidation in
CC       which acetyl-CoA is released and the CoA ester of a fatty acid two
CC       carbons shorter is formed (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains (FadB) and two beta
CC       chains (FadA) (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the thiolase family.
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DR   EMBL; CP000304; ABP79405.1; -; Genomic_DNA.
DR   RefSeq; YP_001172247.1; NC_009434.1.
DR   ProteinModelPortal; A4VKA4; -.
DR   SMR; A4VKA4; 2-391.
DR   STRING; 379731.PST_1727; -.
DR   EnsemblBacteria; ABP79405; ABP79405; PST_1727.
DR   GeneID; 5097811; -.
DR   KEGG; psa:PST_1727; -.
DR   PATRIC; 19963921; VBIPseStu31643_1735.
DR   eggNOG; COG0183; -.
DR   HOGENOM; HOG000012239; -.
DR   KO; K00632; -.
DR   OMA; GIRFDVS; -.
DR   OrthoDB; EOG68M4GV; -.
DR   BioCyc; PSTU379731:GJER-1726-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 4.
DR   HAMAP; MF_01620; FadA; 1.
DR   InterPro; IPR012805; FadA.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   TIGRFAMs; TIGR02445; fadA; 1.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Complete proteome; Cytoplasm; Fatty acid metabolism;
KW   Lipid degradation; Lipid metabolism; Transferase.
FT   CHAIN         1    391       3-ketoacyl-CoA thiolase.
FT                                /FTId=PRO_0000323551.
FT   ACT_SITE     95     95       Acyl-thioester intermediate (By
FT                                similarity).
FT   ACT_SITE    347    347       Proton acceptor (By similarity).
FT   ACT_SITE    377    377       Proton acceptor (By similarity).
SQ   SEQUENCE   391 AA;  41738 MW;  10443DF8691148DA CRC64;
     MSLNPRDAVI VDFGRTPMGR SKGGMHRNTR AETMSAQLID GLLARNPKID PAEVEDVIWG
     CVNQTLEQGW NIARMASLLT RIPHTSAGQT VSRLCGSSMS ALHTAVQAIQ TNNGDVFVIG
     GVEHMGHVSM MHGVDPNPQL SLHAAKASGM MGLTAEMLGK MHGITREAQD QFGYRSHQLA
     WKATQEGKFK DEIIPMEGHD ENGFLKVFDY DETIRPETTL EGLAELKPAF NPKGGTVTAG
     TSSQITDGAS CMIVMSAQRA KDLGLQPMAV VRAMALAGVD PAIMGYGPVP STQKALKRAG
     LTMDDISHVE LNEAFAAQAL PVLKDLKLLD KMEEKVNLHG GAIALGHPFG CSGARISGTL
     LNVMKQNNGT LGVATMCIGL GQGISTVFER L
//
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