ID A4X2Q7_SALTO Unreviewed; 499 AA.
AC A4X2Q7;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ABP53157.1};
GN OrderedLocusNames=Strop_0680 {ECO:0000313|EMBL:ABP53157.1};
OS Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / JCM 13857 / NBRC
OS 105044 / CNB-440).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Salinispora.
OX NCBI_TaxID=369723 {ECO:0000313|EMBL:ABP53157.1, ECO:0000313|Proteomes:UP000000235};
RN [1] {ECO:0000313|Proteomes:UP000000235}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-916 / DSM 44818 / CNB-440
RC {ECO:0000313|Proteomes:UP000000235};
RX PubMed=17563368; DOI=10.1073/pnas.0700962104;
RA Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W.,
RA Jensen P.R., Moore B.S.;
RT "Genome sequencing reveals complex secondary metabolome in the marine
RT actinomycete Salinispora tropica.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:10376-10381(2007).
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DR EMBL; CP000667; ABP53157.1; -; Genomic_DNA.
DR RefSeq; WP_011904591.1; NC_009380.1.
DR AlphaFoldDB; A4X2Q7; -.
DR STRING; 369723.Strop_0680; -.
DR KEGG; stp:Strop_0680; -.
DR PATRIC; fig|369723.5.peg.689; -.
DR eggNOG; COG0318; Bacteria.
DR HOGENOM; CLU_000022_59_0_11; -.
DR Proteomes; UP000000235; Chromosome.
DR GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ABP53157.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000235}.
FT DOMAIN 10..357
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 412..483
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 499 AA; 53713 MW; D2F5F6757F2C8DD3 CRC64;
MTALLHDLLD RTATAQPDTS AISHGDQVQS YRNLNAASRR LASWLAARGV RQGGRVLICL
PTDPLVPALL YACSRAGAVF SMVNEQSPTV ALAHVLTDAE PILLVTDSPR ALAVAVSNGV
PTVGTAELRD VVQDGPDSEP AESPLAVDPI CLIYTSGSTG MPKAVVSTHA QVVFAVKAIA
SQLAYRVDDV VWCALPLSFD YGMYQIFLST LAGARLHLAS PADTGPTLPR HLVSSAATVL
PAVPALARGL ARMLSRPGAT VPALRLLTNT GAAMPPEVLR DLRARIPTLR VQLMFGLTEC
KRAAIMPVDE DLRRPDACGR ALPGTEILVV DADGATVPPD TVGEIVVRGP HVMAGYWRRA
ELTAQRFPRV EGLFPQLRTG DHGWLDAEGY LYFVGRRDDI YKERGIRVSV TEVEAAAYRI
PQIQAAAVLP PRVEDGRDSA TLFVVSELTA PEVLAALRTE LDELKTPRTC LVVPDIPMTR
NGKVDRAELY RMWSEHACV
//
