ID A4XF89_NOVAD Unreviewed; 315 AA.
AC A4XF89;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Dehydrogenase, E1 component {ECO:0000313|EMBL:ABP64600.1};
GN OrderedLocusNames=Saro_3741 {ECO:0000313|EMBL:ABP64600.1};
OS Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG
OS 56034 / CIP 105152 / NBRC 16084 / F199).
OG Plasmid pNL2 {ECO:0000313|EMBL:ABP64600.1,
OG ECO:0000313|Proteomes:UP000009134}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=279238 {ECO:0000313|EMBL:ABP64600.1, ECO:0000313|Proteomes:UP000009134};
RN [1] {ECO:0000313|EMBL:ABP64600.1, ECO:0000313|Proteomes:UP000009134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084
RC / F199 {ECO:0000313|Proteomes:UP000009134};
RC PLASMID=pNL2 {ECO:0000313|EMBL:ABP64600.1,
RC ECO:0000313|Proteomes:UP000009134};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Han C., Thomson S., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Ivanova N., Fredrickson J., Romine M.F., Richardson P.;
RT "Complete sequence of plasmid pNL2 of Novosphingobium aromaticivorans DSM
RT 12444.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP000677; ABP64600.1; -; Genomic_DNA.
DR RefSeq; WP_011906983.1; NC_009427.1.
DR AlphaFoldDB; A4XF89; -.
DR KEGG; nar:Saro_3741; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_5; -.
DR Proteomes; UP000009134; Plasmid pNL2.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Plasmid {ECO:0000313|EMBL:ABP64600.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009134}.
FT DOMAIN 19..304
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 315 AA; 33501 MW; 602FD27DD9BAC0D6 CRC64;
MSGPDPALLE SMFHKLAVSR AVETLMLRHT REERFSGWWH PGEGQEAAPI GATAALEADD
YVWYQGRGCA WAIGKGMDPL PILGDLLGKT NGATGGKGGG VPHWADYSLG IMGEGATLGS
VYPLAAGSAL ASKIRKDGRV SLANFGDGTA SRGTFHETMM HAAAWKLPLI YFCENNGLLV
GTRTEQVSAT ADIANLAKGY GIPGVIVDGQ DAVAVWEATR EAAARARAGK GPTLIEAKVT
RKHGHYAGDP QHYRDPDYLR DYRDPLDLLA ARLAGNVAAR IVEQADAEVA AAYEAARAAP
EPDVSVIERD LYHVV
//
