ID A4XL18_CALS8 Unreviewed; 359 AA.
AC A4XL18;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Mannose-1-phosphate guanylyltransferase (GDP) {ECO:0000313|EMBL:ABP67603.1};
DE EC=2.7.7.22 {ECO:0000313|EMBL:ABP67603.1};
GN OrderedLocusNames=Csac_2018 {ECO:0000313|EMBL:ABP67603.1};
OS Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T
OS 6331).
OC Bacteria; Bacillota; Clostridia; Caldicellulosiruptorales;
OC Caldicellulosiruptoraceae; Caldicellulosiruptor.
OX NCBI_TaxID=351627 {ECO:0000313|EMBL:ABP67603.1, ECO:0000313|Proteomes:UP000000256};
RN [1] {ECO:0000313|Proteomes:UP000000256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43494 / DSM 8903 / Tp8T 6331
RC {ECO:0000313|Proteomes:UP000000256};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A.,
RA VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J.,
RA Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M.,
RA Kengen S.M.W., Richardson P.;
RT "Genome sequence of the thermophilic hydrogen-producing bacterium
RT Caldicellulosiruptor saccharolyticus DSM 8903.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABP67603.1, ECO:0000313|Proteomes:UP000000256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43494 / DSM 8903 / Tp8T 6331
RC {ECO:0000313|Proteomes:UP000000256};
RX PubMed=18776029; DOI=10.1128/AEM.00968-08;
RA van de Werken H.J., Verhaart M.R., VanFossen A.L., Willquist K.,
RA Lewis D.L., Nichols J.D., Goorissen H.P., Mongodin E.F., Nelson K.E.,
RA van Niel E.W., Stams A.J., Ward D.E., de Vos W.M., van der Oost J.,
RA Kelly R.M., Kengen S.W.;
RT "Hydrogenomics of the extremely thermophilic bacterium Caldicellulosiruptor
RT saccharolyticus.";
RL Appl. Environ. Microbiol. 74:6720-6729(2008).
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DR EMBL; CP000679; ABP67603.1; -; Genomic_DNA.
DR RefSeq; WP_011917538.1; NC_009437.1.
DR AlphaFoldDB; A4XL18; -.
DR STRING; 351627.Csac_2018; -.
DR KEGG; csc:Csac_2018; -.
DR eggNOG; COG0836; Bacteria.
DR HOGENOM; CLU_035527_0_1_9; -.
DR OrthoDB; 9806359at2; -.
DR Proteomes; UP000000256; Chromosome.
DR GO; GO:0008928; F:mannose-1-phosphate guanylyltransferase (GDP) activity; IEA:UniProtKB-EC.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005976; P:polysaccharide metabolic process; IEA:InterPro.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF159283; Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000313|EMBL:ABP67603.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABP67603.1}.
FT DOMAIN 5..285
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 318..354
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 359 AA; 41028 MW; 2F3A0E91B12A2270 CRC64;
MQKFAVVMAG GGGTRFWPLS RSSSPKQFLN LSGNDILINE TIDRISKVIP KKNIFIVTNI
NQKEMIEKVL DSEVDRNNII YEPIGRNTAA CILYAALKIK KLHEDGIMCV FPSDHYIKDN
EGFAEVLNTC IEIAEKTDKL ITIGINPTFP STGYGYIKFD KDSQDKYDKK AYEVLEFVEK
PSFDKAKSYI KSGNYLWNSG MFVWKLDTII QNFNRFLPRI YNKFYSIYEY LWTEDEFKYV
SEIYPSLQDI SIDYGIMERA DEVVVVPGDF GWNDVGSWDS LGAIFPPDED GNIIKALHVG
IDTRDCIIYG NNRLIATINV SDVIIAETED AVLVCAKNRA QDVKKIVEML KEKKLDKFI
//
