ID   A4YPV0_BRASO            Unreviewed;       369 AA.
AC   A4YPV0;
DT   29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Putative NAD-dependent epimerase/dehydratasen putative UDP-glucose 4-epimerase {ECO:0000313|EMBL:CAL75926.1};
DE            EC=5.1.3.2 {ECO:0000313|EMBL:CAL75926.1};
GN   OrderedLocusNames=BRADO2069 {ECO:0000313|EMBL:CAL75926.1};
OS   Bradyrhizobium sp. (strain ORS 278).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Nitrobacteraceae; Bradyrhizobium.
OX   NCBI_TaxID=114615 {ECO:0000313|EMBL:CAL75926.1, ECO:0000313|Proteomes:UP000001994};
RN   [1] {ECO:0000313|EMBL:CAL75926.1, ECO:0000313|Proteomes:UP000001994}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ORS 278 {ECO:0000313|Proteomes:UP000001994};
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00007637}.
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DR   EMBL; CU234118; CAL75926.1; -; Genomic_DNA.
DR   RefSeq; WP_011925147.1; NC_009445.1.
DR   AlphaFoldDB; A4YPV0; -.
DR   STRING; 114615.BRADO2069; -.
DR   KEGG; bra:BRADO2069; -.
DR   eggNOG; COG0451; Bacteria.
DR   HOGENOM; CLU_007383_1_7_5; -.
DR   OrthoDB; 9801785at2; -.
DR   Proteomes; UP000001994; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF01370; Epimerase; 2.
DR   PRINTS; PR01713; NUCEPIMERASE.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000313|EMBL:CAL75926.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001994}.
FT   DOMAIN          4..132
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
FT   DOMAIN          164..277
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   369 AA;  39935 MW;  EA5F8B3082477746 CRC64;
     MTRVLITGGA GFIGSHTADA LISAGYEVRL LDTLAPQVHG SQRQRPSYLH ADAELLIGDV
     TDPIAVERAL RGVDKVLHLA SSVGVGQSMY DIESYVRTNE LGTAVLLQAL VNRPVARLVV
     ASSMSVYGEG ACRAGDASVV APEERTLDQL KRGEWELAGA GGALEPIPTP ETKQPTLSSI
     YALNKYAQER MCLITGKAYG IPTLALRFFN VFGPRQALSN PYTGVLAIFA ARLLNDRSPL
     VFEDGLQRRD FVHVHDVARA CVLALESDRV DDVFNVGSGQ SRSIVSVAED LARVMGRSQM
     TPTITGKYRA GDIRHCFADI SKTERLLGFK PAVRFEDGLD ELAHYLADQI ADDQAEKATE
     ELSQRGLVA
//