ID A4Z1I9_BRASO Unreviewed; 490 AA.
AC A4Z1I9;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE RecName: Full=FtsK domain-containing protein {ECO:0000259|PROSITE:PS50901};
GN OrderedLocusNames=BRADO6383 {ECO:0000313|EMBL:CAL80015.1};
OS Bradyrhizobium sp. (strain ORS 278).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=114615 {ECO:0000313|EMBL:CAL80015.1, ECO:0000313|Proteomes:UP000001994};
RN [1] {ECO:0000313|EMBL:CAL80015.1, ECO:0000313|Proteomes:UP000001994}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ORS 278 {ECO:0000313|Proteomes:UP000001994};
RX PubMed=17540897; DOI=10.1126/science.1139548;
RA Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.C.,
RA Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.S., Saunders E.,
RA Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL Science 316:1307-1312(2007).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Translocation stops specifically at Xer-dif sites, where FtsK
CC interacts with the Xer recombinase, allowing activation of chromosome
CC unlinking by recombination. FtsK orienting polar sequences (KOPS) guide
CC the direction of DNA translocation. FtsK can remove proteins from DNA
CC as it translocates, but translocation stops specifically at XerCD-dif
CC site, thereby preventing removal of XerC and XerD from dif.
CC {ECO:0000256|ARBA:ARBA00024784}.
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DR EMBL; CU234118; CAL80015.1; -; Genomic_DNA.
DR AlphaFoldDB; A4Z1I9; -.
DR STRING; 114615.BRADO6383; -.
DR KEGG; bra:BRADO6383; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_556293_0_0_5; -.
DR OrthoDB; 8451223at2; -.
DR Proteomes; UP000001994; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000001994}.
FT DOMAIN 255..442
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 150..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 367..399
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 274..281
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 490 AA; 55068 MW; 934699E951AF557B CRC64;
MSAFSRGEQV YDSRIYDVAR WGFGVPTVYW DPPPRPAEFA FGPEPFEMWG VPFEYYIPKG
SRQAYLVRSG HSEVYADFAM KLMLGRFARE ATRTFAVKAY AGVTEHERKQ TILREAATLA
ETKWFGDLEA DKERVLRELR AGREAKLSRD WAKEASQPDA DAAKRKEALT TAEREIGQAD
KSRLQALRKA EQEIAAAQQA REKAAREAQW AIESAARDRE SQAREAAEQA RVLKLSRPIP
LAPQPGGIVF GTRIKDGVDF VVPLAHLQHI LLSGVSGAGK TVLLHALLHQ LVQSDQVERL
VLIDLKGGVS FNRYRISPKV EVIYEMADVI RVIDQVMALM VQRQNYMREN GIEFWRQRRT
FLVIDEYAEI QTEIDAADTK EAKAEARRLA ANLASISRRA RALGIVMVCA LQRPTTDAMD
AAVRNNLSCR ICLRAATSQL AASMLDDLER LPVRPTELPT GEFYYYDASR GLTRLLKAQI
APGVDLADLF
//
