ID   A5AEN5_VITVI            Unreviewed;      1316 AA.
AC   A5AEN5;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=Integrase catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VITISV_011340 {ECO:0000313|EMBL:CAN66637.1};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN66637.1};
RN   [1] {ECO:0000313|EMBL:CAN66637.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT   vinifera L.): coping with a highly heterozygous genome.";
RL   PLoS ONE 2:e1326-e1326(2007).
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DR   EMBL; AM424683; CAN66637.1; -; Genomic_DNA.
DR   ExpressionAtlas; A5AEN5; baseline and differential.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd09272; RNase_HI_RT_Ty1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR025724; GAG-pre-integrase_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR013103; RVT_2.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR42648:SF22; RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON TNT 1-94; 1.
DR   PANTHER; PTHR42648; TRANSPOSASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF13976; gag_pre-integrs; 1.
DR   Pfam; PF14223; Retrotran_gag_2; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF07727; RVT_2; 1.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SMART; SM00343; ZnF_C2HC; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          279..294
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          523..687
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          230..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          768..787
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1316 AA;  149795 MW;  AF67D97A13AC11E6 CRC64;
     MTTESDNVVV TELAPVATPT VAQVPAMPTA VPISVSPGEK PEKFSGLNFK RWQQKMLFYL
     TTLNLARFLT EDAPKLKEDE HDIQVISAID AWKHSDFLCR NYVMNGLADS LYNVYSDKKT
     AKELWESLDR KYKTEDAGAK KFVVGRFLDY KMVDSKTVVS QVQELQVILH EIHAEGMMLS
     ETFQVAAIIE KLPPAWKDFK NYLKHKRKEM SIEDLIIRLR IEEDNRRSEK KGAHTLNEAK
     ANFVEHGQSS KAKTNNNKGK GSKLGPKGGI SKKPKFQGKC FNCGKQGHKS VDCRLPKKNK
     PKEANVIDDI TKNVYDIDLT AVVSEVNLVG SNPKEWWIDT GATRHVCSDK KMFSTFEPIE
     NGEKVFMGNS ATSEIKGQGK VILKMTSGKE LTLTNVLYVP EIRKNLVSGS LLNNHGFRLV
     FXSNKVVLSK SGMYVGKGYM SDGMWKLNVM TIIKSNMNKA STSTYMLESS NLWHGRLGHV
     NYDTLRRLIN LNHIPTFQIN SNHKCETCVE AKLTRSSFQS VERNTEPLDL IHSDICDLKF
     VQTRGGNKYF ITFVDDSTKY CYVYLLKSKD EAIEKFVLYK TEVENQLNKK IKVLRSDRGG
     EYESPFVDIC AQHGIIHETT APYSPQSNGV AERKNRTLKE MMNAMLISSS LPQNMWGEAI
     LTANYLLNKV PKKKAEKTPY ELWKGRKPSY TYLRMWGCLA KVAVPPPKKV KIGPKTIDCI
     FIGYAHNSNA YRFLVYESNI PDIHKNTIME SRNASFFEDV FPCKSKEEPS SSKRMLESQD
     QNEEVEVEPR RSKRVRTEKS FGPDFLTFML EGEPQTFKEA VNSTEGLMWK EAIKSEIDSI
     LQNHTWELVD LPPGCKPLSS KWIFKRKMKV DGSIDKYKAR LVIKGYRQTE GLDYFDTYSP
     VTRINSIRMV LAIAALRNLE IHQMDMKEIY MEQPEGFSAP GQEKKVCKLV KSLYGLKQAP
     KQWHEKFDNV MLSHGFKINE CDKCVYVKDT EHGYVIVCLY VDDMLIVGSD DKMITSTKNM
     LNSRFDMKDM GLADVILGIK IKRTSNELIL SQSHYVDKIL GKFDKDNSGV ARTPVDVTLH
     LSKNKGESVS QVEYSRIIGS LMYLMSCTRP DIAYAVGKLS RYTSNPGAKH WQGIIRVLKY
     LRFTRDYXLH YTRYPAVLEG YSDANWISNV KDSKSHSGYV FTLGGAAVSW KSSKQTVIAR
     STMESEFIAL DKCGEEAEWL RHFLEDIPRW SKPVPPICIH CDSQSAIGRA QSNMYNGKSR
     HIRRRHNTIR QLLSTGVISV DYVKSKDNIA DPLTKGLNRE LVEKSSXGMX LKPIKE
//