ID   A5AMC2_VITVI            Unreviewed;       855 AA.
AC   A5AMC2;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=VITISV_033508 {ECO:0000313|EMBL:CAN71460.1};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN71460.1};
RN   [1] {ECO:0000313|EMBL:CAN71460.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT   vinifera L.): coping with a highly heterozygous genome.";
RL   PLoS ONE 2:e1326-e1326(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM430065; CAN71460.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5AMC2; -.
DR   ExpressionAtlas; A5AMC2; baseline.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          207..370
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          368..532
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          794..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        794..831
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   855 AA;  96572 MW;  D42243A48EC84A37 CRC64;
     MNTLLNTLLP ILQVRRDGTK MTLAQSKKLS QLTADNAQWE DRQLLRSGAV RGTEVQTEFD
     DEEERKVILL VHDTKPPFLD GRVVFTKQAE PIMPLKDPTS DMAIISRKGS ALVREVHEKQ
     SMNKSRQRFW ELAGSKLGDI LGVEKTAEQI DADTAVVGEE GEVDFKEDAK FAQHLKKDEA
     VSEFAKSKTL AEQRQYLPIY SVREELLQVI RENQVVVVVG ETGSGKTTQL TQYLHEDGYT
     TNGIVGCTQP RRVAAMSVAK RVSEEMETEL GDKVGYAIRF EDVTGPNTKI KYMTDGVLMR
     ETLKDSELDK YRVVVMDEAH ERSLNTDVLF GILKKVVAQR RDFKLIVTSA TLNAQKFSNF
     FGSVPIFHIP GRTFPVNILY SKTPCEDYVE GAVKQAMTGC LSSQYSLYTP QLPADLQAKI
     FQKAEDGARK CIVATNIAET SLTVDGIFYV IDTGYGKMKV YNPRMGMDAL QVFPVSRAAA
     DQRAGRAGRT GPGTCYRLYT ESAYLNELLA SPVPEIQRTN LGNVVLLLKS LKIENLLDFD
     FMDPPPQDNI LNSMYQLWVL GALNNVGGLT ELGWKMVEFP LDPPLAKMLL IGEQLECINE
     VLTIVSMLSV PSVFFRPKDR AEESDAAREK FFVPESDHLT LLNVYQQWKA NQYRGDWCND
     HFLHVKGLRK AREVRSQLLD ILKTLKIPLT SCGPDWDVVR KAICSAYFHN AARLKGVGEY
     VNCRNGMPCH LHPSSALYGL GYTPDYVVYH ELILTAKEYM QCATAVEPQW LAELGPMFFS
     VKDSDTSMLE HKKRQKEEKS AMEEEMENLR KEQEEAERKS KEKERKKRAK QQQQVSMPGL
     RQGSSTYLRP KKMGL
//