ID A5BRI1_VITVI Unreviewed; 1957 AA.
AC A5BRI1;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE Flags: Fragment;
GN ORFNames=VITISV_030726 {ECO:0000313|EMBL:CAN59913.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN59913.1};
RN [1] {ECO:0000313|EMBL:CAN59913.1}
RP NUCLEOTIDE SEQUENCE.
RA Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT vinifera L.): coping with a highly heterozygous genome.";
RL PLoS ONE 2:e1326-e1326(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM468432; CAN59913.1; -; Genomic_DNA.
DR ExpressionAtlas; A5BRI1; baseline.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 3.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
FT DOMAIN 1700..1789
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 27..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..60
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1957
FT /evidence="ECO:0000313|EMBL:CAN59913.1"
SQ SEQUENCE 1957 AA; 218523 MW; 40FE5C155EE4238E CRC64;
MDSQIVTVDQ FVEAMASIQE AIASLGRRID GQQAQQXPPP IGAQYDPTVP PPPPPSQSAP
QAMPFTLHSQ TGVAPPPITV PTPTSEDPHA RMDRLEQGLR QLRASDRATT WEGFDGVPVA
SLPAKFRMPD IERYTGIGCP RLHLRLYXTV MRAHGLDEPQ MITLFPLSLS GAAQRWFASL
EASRRRTWDD LAXEFLRQFS FNTVVDVSRR ELEALRQRTE ESVSSFISRW RGKIAEIIDR
PSERDQIXMV LRSLQPRIAR HVVEAPFTDF GSLVMALYDV EDGISRGLWT DSSPSDVKGK
KPFVGQRSTD VSAISSSSMP LSQALRKLTE AGLLTTLTPR PSPQPIPPQF RTDLHCAYHQ
GPGHETDRCT ALRHAVQDLI DQGLVHLGQP SVTTNPLPAH TTHAVPPPAD GIHFLEFDEI
DDHIHMLSDD DPDPEPIMPD VIYEXSGVTL GPXXPAPFRL VPEAASVQAA TVDDSQTLDI
QYVLRGGRVM RQPPPAAAAR PLGGTSSQEE VRVEDDEILR QLQSTQARIS IWSLLASSXT
HRDALTRALS QIRVDTTTTP EGLIHMMTAG RATXIVFSDD DLPPEGSGHT RPLYISVGCS
GRRVPSVLLD NGSALNVCPL ATAIALGYAP SDFGPSTQTV RAYDSTRREV MGTLEIELLI
GPTTFITIFQ VLRIPTSFNL RLGRPWIHRA GAIPSSLHQK VKFIHEGQVV VVQSAGDMFI
SAEPVLQISX SDDDLLLTGF TFDEVXTLEL GDFCRDFIAM SFDQHGSTVV LDIMRGMSYL
PGMGLGRRQH GPSEFITIPD HDXPFGLGFI PTEADYRYMA RLRKERXRAR LTHTPFDYPL
RPYTRSLSDY FVRASESHAP SDGIIGGLST TQEAELQRLV QQLQLSDGAP GPSASVLIAP
PSPDRTSLMT LCFPDEIDDH GTFAEIGDVV DGVVLRDEYV DEMLVMSLSX TEEMAPXELA
SPFDLFGVSV LEIAEEIQVA PTPEXVEDVI VAVDLFDGPV GLVEGASDLV DPPLTFDVLS
GFVSRHDYVS DFSSMDLSTF EYLPVSHVID LSAPSSPTSQ IFDIDDEIAQ HDSDDDSSSA
SDSDPVDQRV SPAVGDTEIV DFGTADQPRE LRIGSDLSTD ERDSLIQLLR SYLDVFAWSY
EDMPGLDPSI VQHRLPLLPX ARPVKQKLRR LHPRWSLQVK EEIQKQLSVG FLSVVEYPEW
LANVVPVPKK DGKVRVCVDF RDLNKASPKD DFPLPHIDML VDSTAGHSML SFMDGFSGYS
QILMAPEDME KTSFITEWGR PLLLYLSVSD VALGCMLAQL DDSGKDRAIY YLSKRMLDYE
TRYVMIERYC LALVWATRRL RHYMTEYSVH LISRLDPLRY LFDRPALVGR LMRWLVLLTE
FDIHYVTQKS IRGSIVADHL ASLPVSDARA IDDDFPDEDV AAVTSLSGVL LISPHGDHIP
RSVRLAFSDR HPATNNIVEY EACILGLETA LELGIRQMEV FGDSNLVLXQ IQGEWKTRDV
KLKPYHAYLE LLVGRFDDLR YTHLPRAQNQ FADALATLAS MIDIPVDATV XPLLIESRSA
PAYCCLIDDV EPDDGLPWYH DIYHFLRLGV YPEAATAKDK RALRQLATRF MICGETLYRR
SPDGMLLLCL DRAXADRVMR EVHAGVCGPH MXGHMLARKI MRTGYFWLTM ETDCCQFVQR
CPECQIHGDF IHVPPSELHA LTSPWPFSVW GIDIIGKISP KSSSGHEFIL VAIDYFTKWV
EAASYARLTS SGVASFIRSH IICRYGVPHE LISDRGVHFR AETNGAVEAA NKNIKRILRR
MVETSRDWSE KLPFALWAYR TSFRTSTGAT PYSLVYGMEA MLPVEIEMGS LRVALEQQIP
EXDWAQARFD QLNLLDXRRL RAADHVCAYQ RKMXRAFKKR VKPRPLXIGD LVLKVIRGLI
RDPRGKFRPN WSGPYFIREL TPEGXAWLMD LDGNRFX
//
