ID   A5BW22_VITVI            Unreviewed;      1258 AA.
AC   A5BW22;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN   ORFNames=VITISV_030718 {ECO:0000313|EMBL:CAN70623.1};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN70623.1};
RN   [1] {ECO:0000313|EMBL:CAN70623.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT   vinifera L.): coping with a highly heterozygous genome.";
RL   PLoS ONE 2:e1326-e1326(2007).
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DR   EMBL; AM473236; CAN70623.1; -; Genomic_DNA.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd00303; retropepsin_like; 1.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
FT   DOMAIN          948..1112
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
SQ   SEQUENCE   1258 AA;  144777 MW;  66C92AB9A2424ACB CRC64;
     MNAIPXKELL KEEMLKKSTS PPFPQALHGK KGIRNASEIL EVLRQVKVNI PLQDMIKQVP
     TYAKFLKDLC TIKRGLTVNK KVFLTEQVSA ILQCKSPLKY KDPGRPTISI MIGGKVVEKA
     LLDLGESVNL LPYSIYKQLG LGELKPTTIT LSLADRSVKI PRGXIEDVLV QVDNFYYPVD
     FIVLDTDPTP FLATSNAIIN CRNGLMQLTF GNMTLDLNIF YMSKKQTTPE EEEGPEELCI
     IDTLVEEHCN QNIQDKLNES LVDFEEGLFE SPTVLATLQS WRKIEEILPV FNKEEEAAVE
     KETPKLNLKP LPVELKYTYL EENNQCPVMI SSSLTSHQEN CLMEVLKRCK KAIGWQISDL
     KGISPLVCTH HIYMEEEAKP IQVVQAEVLK LLQAGIIYPI SDSPWVSPTQ VVPKKSGITV
     VQNEKGEEIT TRLTSGWRVC IDYRKLNAVT RKDHFPLPFI DQVLERVSGH PFYCFLDGYS
     GYFHIEIDVA DQEKTTFTCP FGTYAYRRMP FGLCNAPATF QRCMLSIFSD MVERIMEVFM
     DDITVYGGTF EECLINLEAV LHKCIEKDLV LNWEKYRFMV HQGIVLGHII SEKDIEVDKA
     KVELIVKLPS PTTVKGVRQF LGHTGFYRRF IKGFSSLSKP LCELLAKDAK FIWDERCQNS
     FDQLKKFLTT TPIVRALNWQ LPFELMCDAS DFAIGAVLGQ REDGKPYVIY YASKTLNEAQ
     RNYTTTEKEL LVVVFALDKF RAYLVGSFII VFTDHSALKY LLTKQDAKAR LIRWILLLQE
     FDLQIKEKKG VENVAADHLS RLVITHNSHP LPINDDFPEE SLMFLVKTPW YAHIANYLVT
     GEIPSEWNAQ NRKHFFAKIH AYYWEEPFLF KYCADQIIRK CVPEDEQQGI LNHCHENACG
     GHFASQKTAM KVLQSGFTWX SLFKDAHIMC RSCDRCQRLG KLTKRNQMPM NPILIVELFD
     VWGIDFIGPF PMSFGNSYIL VXVDYVSKWV EAIPCKQNDH RVVLKFLIEN IFSRFGVPKA
     IISDGGAHFC NKPFEALLSR YGVKHKVATP YHPQTSGQVE LANREIKNIL MKVVNSSRKY
     WSIRLHDSLW AYRTAYKTIL SMSPYRLVYG KACHLPVEVE YKAWWTIKKL NMDLIRAGEK
     RYLDLNEMEE LRNDAYINSK VAKQRMKKWH DQLISNKEFQ KGQRVLLYDT RLHIFLGKLK
     SRWIGPFIIH QVYANGVVEL LNSNGKDTFR VNGYRLKPFM EPFKPEKEEI NLLEPQKA
//