ID A5C4F7_VITVI Unreviewed; 812 AA.
AC A5C4F7;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 22-FEB-2023, entry version 62.
DE RecName: Full=Ku domain-containing protein {ECO:0000259|SMART:SM00559};
GN ORFNames=VITISV_004463 {ECO:0000313|EMBL:CAN68627.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN68627.1};
RN [1] {ECO:0000313|EMBL:CAN68627.1}
RP NUCLEOTIDE SEQUENCE.
RA Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT vinifera L.): coping with a highly heterozygous genome.";
RL PLoS ONE 2:e1326-e1326(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM481988; CAN68627.1; -; Genomic_DNA.
DR ExpressionAtlas; A5C4F7; baseline and differential.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 393..534
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 638..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 91168 MW; 9F7092CD2780615F CRC64;
MSTCXWRNXS ADKLIYSKND EVGIVLFGTE DTNNELTKEV GGYEHVVVLR HIKVVDGDLV
EALQQLPRGT VAVLDAIVVG MDMLIKKFGS TNKGKKRLCL ITSALCPIKD PYEGTKEDQI
GTIAEQMSAH GMKLECIVAR GRLSGNVDMR IMDENDLLLK LFSTKTTAKT LYVETPTSLL
GALRTRSIAP VTIFRGDLEL SPKMRIKLNI LVSTIAPSYD YPDAFGYVIA RSWACALAVC
LAVYRRGHAI ALQFMFSCSF TLWMNGEGTE ATCWLECIVK RSLGENEDEL RAQGGCFSEG
STPENLKSWG ATWAILLVRT NSSLIMLLLQ ISSCSVLDAV LERPVKAVWV YKKTAEXRFP
TLKQYSDQAP PTDKFATHEV KVDFEYKSVE ESSKVVPPEQ RIKGYRYGPQ VIPISSAEWE
AVKFKPEKGV KLLGFTDASN VMRHYYMHDV NIFIAEPGNT KAMLTVSALA RAMKEMNKVA
ILRCVWRQGQ GSVVIGILTP NVSDKDDIPD SFYFNVLPYA EDVREFQFPS FSNLPASWQP
NEEQQEAADN LVKMLDLAPS GSRETLLPDL TPNPVLERFY RHLELKSKHP DAAVPPLDES
LKKITEPDPK LLSQNKPIID AFRRRFELKE NPKLKKSTRR LXRXRPSGLN EEASMGDGSD
GQAIKSIENT STVGVEKIGD STPIQDFEAM MSRRDSPEWV GKAINEMKNK IFDLVEDSYE
GDNYLKALEY LVALRKGCVL EQEPKQFNDF LHHLYKYCEK HNLNSFCESL ASKEIMLINK
TEAADRWSVK NRIGFGGQVT YREGTVKIVA PL
//
