ID A5C7I8_VITVI Unreviewed; 1441 AA.
AC A5C7I8;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=VITISV_004613 {ECO:0000313|EMBL:CAN66453.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN66453.1};
RN [1] {ECO:0000313|EMBL:CAN66453.1}
RP NUCLEOTIDE SEQUENCE.
RA Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT vinifera L.): coping with a highly heterozygous genome.";
RL PLoS ONE 2:e1326-e1326(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; AM485060; CAN66453.1; -; Genomic_DNA.
DR ExpressionAtlas; A5C7I8; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF585; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00255; TIR; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 25..191
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 224..382
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1396..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1410..1427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 312
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:CAN66453.1"
SQ SEQUENCE 1441 AA; 163549 MW; DE8C7174DC05FCD8 CRC64;
MAFADPQSQR ASSSSSSSSI STRGWNYDVF LSFMGEDTRH NFTDHLYRAL DQKGIRTFRD
HEELRRGEEI AAELLKAIEE SRICVVILSK NYARSRWCLD ELVKIMGWKK CMGQLVLPIF
YQVDPSNVRK QKGSYXEALA DHERNADEEG MSKIKRWREA LWNVGKISGW PEAHVIEEIT
STIWKSLNRE LLHVEKNLVG MDRRRVSSSS SSSSTSTSTC IGPWEYEVFL SFRGQDTRQN
FTDHLYSALS QKGIRTFRMD HTKGEMILPT TLRAIEMSRC FLVILSKNYA HSKWCLDELK
KIMESRRQMG KXVFPVFYHV NPSDVRNQGE SYGEALXNHE RKIPLEYTQK LRAALREVGN
LSGWHIQNGF ESDFIXDITR VILMKFSQKL LQVDKNLIGM DYRLEDMEEI FPQIIDPLSN
NVXMVGIYGF GGIGKTTMAK VLYNRIGAQF MITSFIANVR EDSKSRGLLY LQKQLLHDIL
PKRKNFIRNV DEGIHMIKDR LCFKKVLLVL DDVDDLNQLE ALAGDHNWFG PGSRIIVTTR
DKHLLEVHEM DALYEAKKLD HKEAVELFCW NAFKQNHPKE DYKTLSNSVV HYVNGLPLGL
KREPNQEIQR VLKRSYDVLD YTQQXIFLDV ACFFNGEDKD FVTRILDACN FYAXSGIGVL
GDKCFITILD NKIWMHDLLQ QMGRDIVRQE CPKDPGKWSR LCYPEVVNRV LTRKMWDLEX
AFMREDNKVK LSKDFEFPSY ELRYLHWHGY PLESLPLGFY AEDLVELDMC YSSLKRLWEG
DLLLEKLNTI RVSCSQHLIE IPDIIVSAPN LEKLILDGCS SLLEVHPSIG KLNKLFLLNL
KNCKKLICFP SIIDMKALEI LNFSSCSGLK KFPNIQGNME NLLELYLAST AIEELPSSIG
HLTGLVLLDL KWCKNLKSLP TSICKLKSLE NLSLSGCSKL ESFPEVTENM DNLKELLLDG
TPIEVLPSSI ERLKGLILLN LRKCKNLVSL SNGMCNLTSL ETLIVSGCSQ LNNLPRNLGS
LQCLAQLHAD GTAIAQPPDS IVLLRNLQVL IYPGCKILAP NSLGSLFSFW LLHGNSPNGI
GLRLPSSFSS FRSLSNLDIS DCKLIEGAIP NGICSLISLK KLDLSRNNFL SIPAGISELT
NLKDLRLGQC QSLTGIPELP PSVRDIDAHN CTALLPGSSS VSTLQGLQFL FYNCSKPVED
QSSDDKRTEL QIFPHIYVSS TASDSSVTTS PVMMQKLLEN IAFSIVFPGT GIPDWIWHQN
VGSSIKIQLP TDWYSDDFLG FALCSVLEHL PERIICHLNS DVFDYGDLKD FGHDFHWTGN
IVGSEHVWLG YQPCSQLRLF QFNDPNEWNH IEISFEAAHR FNSSASNVVK KCGVCLIYAE
DLEGIRPQNR KQLKSSGCNV VERSSDRAGL NRSGMESSSS GSRHGPTNDP TLKLKRKRPQ
E
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