ID A5CFB0_ORITB Unreviewed; 805 AA.
AC A5CFB0;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Type IV secretion system protein {ECO:0000313|EMBL:CAM81045.1};
GN Name=virB4 {ECO:0000313|EMBL:CAM81045.1};
GN OrderedLocusNames=OTBS_1950 {ECO:0000313|EMBL:CAM81045.1};
OS Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Orientia.
OX NCBI_TaxID=357244 {ECO:0000313|EMBL:CAM81045.1, ECO:0000313|Proteomes:UP000001565};
RN [1] {ECO:0000313|EMBL:CAM81045.1, ECO:0000313|Proteomes:UP000001565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Boryong {ECO:0000313|EMBL:CAM81045.1,
RC ECO:0000313|Proteomes:UP000001565};
RX PubMed=17483455; DOI=10.1073/pnas.0611553104;
RA Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y.,
RA Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S.,
RA Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.;
RT "The Orientia tsutsugamushi genome reveals massive proliferation of
RT conjugative type IV secretion system and host-cell interaction genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007).
CC -!- SIMILARITY: Belongs to the TrbE/VirB4 family.
CC {ECO:0000256|ARBA:ARBA00006512}.
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DR EMBL; AM494475; CAM81045.1; -; Genomic_DNA.
DR RefSeq; WP_011945113.1; NC_009488.1.
DR AlphaFoldDB; A5CFB0; -.
DR KEGG; ots:OTBS_1950; -.
DR eggNOG; COG3451; Bacteria.
DR HOGENOM; CLU_008341_3_0_5; -.
DR Proteomes; UP000001565; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR004346; CagE_TrbE_VirB.
DR InterPro; IPR018145; CagE_TrbE_VirB_cntrl_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR043964; P-loop_TraG.
DR NCBIfam; TIGR00929; VirB4_CagE; 1.
DR PANTHER; PTHR30121:SF6; TYPE IV SECRETION SYSTEM PROTEIN CAGE; 1.
DR PANTHER; PTHR30121; UNCHARACTERIZED PROTEIN YJGR-RELATED; 1.
DR Pfam; PF03135; CagE_TrbE_VirB; 1.
DR Pfam; PF19044; P-loop_TraG; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001565};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 449..707
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 805 AA; 90621 MW; 5CEBDD8474C8824A CRC64;
MKFFKTKVAR EYYSKREVHV AKFIPYAYHW NKSTIITKKN ELIKVIKISG FAFETADDQD
LDIRKRLRNL LFKGMASGSL NLYFHIIRRR KQLASAMDEG DIDPTAGRAK DFVTYVDNEW
KKKYSDFQSF VNDIYITILY KPDVEGGEIL KYFYNKLLQK SDKNAWMQSM NEMYANLDEM
VSRVVTTFSD YDAQILKVKN EPNGVFCEIL EFLATIVNCG SSMPVLLPRG SIDSYIPTHR
LFFGDRSIEA RGAGQRRYAG IVSIQEYGPK TSAGVLDSFL QLPFELIISQ SFQFSSRTAA
INKMQLQQNR MIQTEDKAVS QIAEISQALD MATSGEIGFG EHHLTVLCIA DSLKALENAL
SIASVEIANT GMQPVREKVN LEAAYWAQLP GNIEYAVRKS VINTLNLAGF ASMHNYLPGK
AKGNHWGDSV TVLDTSSGTP FYFNFHVRDV GHTLLIGPTG AGKTVLMNFL CAQAQKFYPR
TFFFDKDRGA EIFIRALDGK YTVINPFQQC NFNPLQLPDT NENRNFLVEW IKTLVTSNGE
SISADDMHYI TLAVEGNYKL NPSDRYLSNI VAFLGIGGPD TLAGRIAIWH GTGAKAGIFD
NIHDNMDLQS GRVFGFEMGE LLKDPVSLAP VLLYLFHRIN LSLDGSPTMI VLDEAWALID
NPVFAPKIKD WLKVLRKLNT FVIFATQSVE DASKSSISDT LIQQTATQIF LPNLKATDIY
RTAFMLSERE FSIIKSTDPG SRYFLIKQGI GSVVAKLNLA GMNNIIGVLS GRVETVILLD
QLRSEYGDDS RKWLPKFYKH LETAK
//
