ID A5CFJ0_ORITB Unreviewed; 442 AA.
AC A5CFJ0;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Phage-related integrase {ECO:0000313|EMBL:CAM81175.1};
GN Name=int {ECO:0000313|EMBL:CAM81175.1};
GN OrderedLocusNames=OTBS_2080 {ECO:0000313|EMBL:CAM81175.1};
OS Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Orientia.
OX NCBI_TaxID=357244 {ECO:0000313|EMBL:CAM81175.1, ECO:0000313|Proteomes:UP000001565};
RN [1] {ECO:0000313|EMBL:CAM81175.1, ECO:0000313|Proteomes:UP000001565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Boryong {ECO:0000313|EMBL:CAM81175.1,
RC ECO:0000313|Proteomes:UP000001565};
RX PubMed=17483455; DOI=10.1073/pnas.0611553104;
RA Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y.,
RA Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S.,
RA Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.;
RT "The Orientia tsutsugamushi genome reveals massive proliferation of
RT conjugative type IV secretion system and host-cell interaction genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007).
CC -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC {ECO:0000256|ARBA:ARBA00008857}.
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DR EMBL; AM494475; CAM81175.1; -; Genomic_DNA.
DR AlphaFoldDB; A5CFJ0; -.
DR KEGG; ots:OTBS_2080; -.
DR eggNOG; COG0582; Bacteria.
DR eggNOG; COG4974; Bacteria.
DR HOGENOM; CLU_027562_17_7_5; -.
DR Proteomes; UP000001565; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd00796; INT_Rci_Hp1_C; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 3.30.160.390; Integrase, DNA-binding domain; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR038488; Integrase_DNA-bd_sf.
DR InterPro; IPR025166; Integrase_DNA_bind_dom.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR PANTHER; PTHR30629; PROPHAGE INTEGRASE; 1.
DR PANTHER; PTHR30629:SF2; PROPHAGE INTEGRASE INTS-RELATED; 1.
DR Pfam; PF13356; Arm-DNA-bind_3; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000001565};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 119..197
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 217..409
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
SQ SEQUENCE 442 AA; 51517 MW; D24DE973A9E8C725 CRC64;
MINMPVTVFK FTQAALNKMQ VPTKEENTFQ CRDEKERNLV FIISYTGFRR LYLGININGM
YYKIKIGDFP DLTVAEARKK IQQLKRDIAK GINPMDERRK INKERREKRE KRLKLKNELT
FRQVHEKYTE YSSHHHRSWK RTSERVKIYA AFLYNKKISE ITKEDIQKIF DEITARKHYV
TANNILMNLS PIFNKAIEWG LIDKNPVHGI KRHKQESRSR YVTNEEMERL MKVLVEKENS
QLTEEQKQSK ISETLFLFIA LFTAARSGNI LAMRWDEISL SEKIWCIPKT KSKNGKQLYI
GLADKLIAVL QNRKLCSKSE WILPSVKDNS KHISSSTIHR AWAKIRKKAG IPNVTIHDLR
RTFATWMINN GETVDTISQI LGHSNTNTTK IYIIHSLAMA KIATNKVVEN MLRIFGPNVC
LNEILSGILP SLSFGEEKLT TT
//
