ID A5DB80_PICGU Unreviewed; 2224 AA.
AC A5DB80;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 2.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN ORFNames=PGUG_00535 {ECO:0000313|EMBL:EDK36437.2};
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK36437.2, ECO:0000313|Proteomes:UP000001997};
RN [1] {ECO:0000313|EMBL:EDK36437.2, ECO:0000313|Proteomes:UP000001997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC Y-324 {ECO:0000313|Proteomes:UP000001997};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
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DR EMBL; CH408155; EDK36437.2; -; Genomic_DNA.
DR RefSeq; XP_001487158.1; XM_001487108.1.
DR STRING; 294746.A5DB80; -.
DR GeneID; 5129696; -.
DR KEGG; pgu:PGUG_00535; -.
DR VEuPathDB; FungiDB:PGUG_00535; -.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_000443_2_0_1; -.
DR InParanoid; A5DB80; -.
DR OMA; FIACFWL; -.
DR OrthoDB; 1386981at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001997};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 698..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 934..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 961..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 996..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1028..1049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1110..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1334..1356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1408..1426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1464..1485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1579..1601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1659..1676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1688..1709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1721..1741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1784..1806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1870..1895
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 621..856
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 904..1140
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1336..1610
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1660..1905
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2191..2224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2198..2224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2224 AA; 255131 MW; EE69C3B6548B32BB CRC64;
MSSPSDSRGL WQNQGSSSRD PSPLSARFAS RHSSRRVSRN PFDDNYVDPD EHAHLTANVS
GDNSFHQSPD HSHRLSILST NHADRSHTAA RQSSSFNPFR DQEPNSNPPI PEPKSFIDEA
TKASDFEALQ EGLNFALGSH DKHANWFPVN ENKSSEDIRR HVSNTSAEAD LAHAYSNDDV
YTETIPLENL PSNSPLHQHP SLIDSSSTPF PFHKVDKKGP SRRAPPNLTV IPPQDLESGR
LSPMTPQLAV GTPTSKFADV LVRVSDRIAG SGNVAKSPTI ETPHLPLSRE NSSLMKPDDN
HSLQPHYSGR NDSFSEYLRG ENNSVPDVTI TDENNKTNRA DDESDLGGLG LYLSNDTFAN
KPKHSSPKKD HTDQLSDPGT IAPPIARYPK QGEFPIQDSL YLYGKSLKIF PPSSPIRRFA
YGVSCNSFTN LFLLALLSFQ VVLLTYRQWN PPALDGYFYS GYNWADYTLI GVNLIYTIEI
ILKCIAFGLI DDSQMYAELG IAREIDRRSL FRPYYIIKFL EYLRLKNPRK RKYIVPGKGK
FHDSAYDSSD EGDHGIDNSG NNGKESTDQA NRGIHTIQDK YSRSSIDERA GLSEGNPPVK
TQLLPSNTLM LPKKEIDIDA LHLKRAYLKN SWQQVDFISM VTFWISLALS IDHYDAKHHI
MLFRALSCLR IVRLCNMTTG TTTILTACRA ALPQLIDVSI FIACFWLLFG IIGVQSFKSS
LTRHCVWTNP QNSTDTFINS EQYCGSYTDL DGTARPYLFR DGTESSYVKG YRCPKNSKCI
SGDNPYNGTV NFDNILQSME LVFVVMSANT FTDIMYYTMD SDNLGACLFF IFCIFIMTVW
LINIFIAVIV TSFNITRMEQ QDQEKSSRTS TLLFLKFFDR TGRKNLARLD ELKRSHRPLR
IYYKFEFVFV IVIIAAMFTQ CFRKHGMDDY RRHLLYRFEC VYTVILLAEI VIRFAMHLPH
WRLFFVSNRN CFDLFLAVFT FIIIIEPVKD KLGQGYYWLT VFQLMRFYRV VLATSFTRDL
WMKIMVNFRA LFDLTLFFFI LTFVVSIIVS RYYEGAIPVD DISDLDFPLH TLPNTFVGLY
TITSTENWTD VLYGVQEYAT TTSYRSFGSV LLICWFIVSN MIILNIFIAI IAKTLEVSEE
DKRKEQLHQF MDNMTTRLQT LETEVDFLSR FKSKFFKRNA IRDELEKAVV NLLLSGTAVN
DFLDTNEESD SDDALERDNG SVSTLSTVKW KRWIQVRMAR LTSHLRNPFF AKQTHTHNVT
DFDPAAFAKN IISDRNVLIS KQNKFLQENP NFNKVFYILE PRHPVRRCCQ RLVKSSHGER
IDGVEPNKKV SEAIVFFMFL VTLALVIAAC YLTPLYRKSV DQVHGKYNWT FYLDNGFLAI
FTIEFLIKIL ADGLIFTPNA YVMSSWNIID LWVLLALWIE FIAFMQNDGN LSRFIRGFKA
LRALRLLTIS EVAKNNFQHT MITGFWKIIN AALISLCLLF PFSIWGLNVF NGRLGYCLDG
SSDQDHCLNE YDNEVFNWNI YSPNVYTNPQ LEFNRWATSF ATFFEIVSLE GWTDLLINVM
KSTGVGTPQE DFASPMNGFM IILFNFVSMV FILTLFVSVI ISNYSRTTGR AYMTKNQISW
YQIKRFLVQV RPSKRMSLAE MSTFRRFCYR MTVEKNVNWS RILTCVLTAQ VAALLMECFP
SSTGLDKART AVYIFASTFL LLQAIMKMIG QGWRTFVRYK WNTFSFFVSL GAFVTSLIGL
FISAESAFIN INKLFLVATL TFIIPRSDRL SQLLRFASAS LPSLLSLSFT WIVVFLVFAI
ALNQIFGLTR IGPNGTGNLN LRSVPKALIV LFRCSFGEGW NYIMEDYTIE APFCYSAHSL
DDSDCGNKQY AYILFIAWNL ISMYIFLNMF VSLILDSFSY INSATAYSHL IDREEVREFK
RTWQKFDPEG TGYIRPYYLP KLLHSLNGAI SFHFYSGSLT IPELCKKWIT RNDINNPYDI
TINYSAVEGT MQSMDIEKIR ERRKLYEMFI EEALLTMELN QDPGISFTRI LLQLPLYTYF
EAGSCLDLID FLERRLLLQK VKKRLHTKRV YETIAAYSCR WKYAKDRRLG IRDTNIDFTE
NLRRSSYLST EYPESRSSGS DRSSRVVDDF TTIPRKPDLF NDDEAASPLL EEDKMYIPNS
PLHTYNGKGS REGGSVSNVP KFEVHDMGSI DTFESPFADP QRGKRKRDKN LSLIDLTLDE
EGQK
//
