ID A5DFM6_PICGU Unreviewed; 535 AA.
AC A5DFM6;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 2.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=Anaphase-promoting complex subunit 4-like WD40 domain-containing protein {ECO:0000259|Pfam:PF12894};
GN ORFNames=PGUG_02077 {ECO:0000313|EMBL:EDK37979.2};
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK37979.2, ECO:0000313|Proteomes:UP000001997};
RN [1] {ECO:0000313|EMBL:EDK37979.2, ECO:0000313|Proteomes:UP000001997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC Y-324 {ECO:0000313|Proteomes:UP000001997};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR EMBL; CH408156; EDK37979.2; -; Genomic_DNA.
DR RefSeq; XP_001486406.1; XM_001486356.1.
DR AlphaFoldDB; A5DFM6; -.
DR STRING; 294746.A5DFM6; -.
DR GeneID; 5127936; -.
DR KEGG; pgu:PGUG_02077; -.
DR eggNOG; KOG0305; Eukaryota.
DR HOGENOM; CLU_014831_4_1_1; -.
DR InParanoid; A5DFM6; -.
DR OMA; WSKNTDE; -.
DR OrthoDB; 20041at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:InterPro.
DR GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF1; FIZZY-RELATED PROTEIN HOMOLOG; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001997};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 256..323
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 267..308
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 350..382
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 392..436
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 480..513
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 59517 MW; 5BC187F3ACD9AEEC CRC64;
MAPLETPKSP SRSTRNIDPP RVDEAPSLPS MSPRRRTQKP IFSDRYIPNR TGVDLQAAFS
LSSQEVLPDL RRRGDADNEI QIRKEEEANR TFSTVLKAEL FGDNVPMATA NLASPRAKKP
PSSNSLSDPD SSTPSNSGSA PSSSNGRDRT PPRSANHDDI TSTPRQSTNL FTYQSPKKSR
PISRDLQNEL YSLSPVRQDS QKLLLSPQKK PRNISKVPYR VLDAPELSDD FYLNLVDWGQ
QDILAVGLGD SVYLWDGATQ SVDRLCNLSN KDKVTSINWI GSGTHLAIGT SQGLVEIWDA
TKMKCVRTMT GHSLRVSSLS WNEHILSSGS RDRSILNRDV RVESHYINKF EHHKSEVCGL
RWNVDENKLA SGGNDNRVFV WDGLNTTPVH EFSEHVAAVK ALAWSPHQRG ILASGGGTTD
KTIKVWNTLT GSKVQDVNTG SQVCNLIWSR SSNELVSTHG YSRYQIVVWK YPSMQQIAQL
TGHTSRVHYL SLSPDGETIV TGAGDETLRF WNVFEKNRND EPPSSVLLDA FSQLR
//
