ID A5DUV6_LODEL Unreviewed; 736 AA.
AC A5DUV6;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Sorting nexin-41 {ECO:0000313|EMBL:EDK42964.1};
GN ORFNames=LELG_01142 {ECO:0000313|EMBL:EDK42964.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK42964.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK42964.1, ECO:0000313|Proteomes:UP000001996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; CH981524; EDK42964.1; -; Genomic_DNA.
DR RefSeq; XP_001528622.1; XM_001528572.1.
DR AlphaFoldDB; A5DUV6; -.
DR STRING; 379508.A5DUV6; -.
DR GeneID; 5235668; -.
DR KEGG; lel:LELG_01142; -.
DR VEuPathDB; FungiDB:LELG_01142; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_025790_0_0_1; -.
DR InParanoid; A5DUV6; -.
DR OMA; NSHEIHI; -.
DR OrthoDB; 5475877at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd06867; PX_SNX41_42; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR044106; PX_Snx41/Atg20.
DR PANTHER; PTHR46979; SORTING NEXIN-41; 1.
DR PANTHER; PTHR46979:SF2; SORTING NEXIN-41; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996}.
FT DOMAIN 158..282
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 83844 MW; 6C014EE40B64489A CRC64;
MSNGNLFDDI EEDNNPSFYY GNPSILTDPY HTTSNSNSSS NNNNNSNNNN SAEQNAENKK
EIKTSGAIKT QGATRANGSN KSKTNSNKQS KNHKSSSPSS IPPPSSQKQQ QQEQQQQQQQ
QQQQQINKTF QLHTDDEYPT DLVNSTIGLS NKITQLLNSK DLKIDIVNSE KLINSSIIVY
TILLVSEKID SKIVVKRRYS EFKSLRDNLI RLFPTLIIPP IPEKHSILSY LLTTINTDNE
SNIIEMRKRY FKLFLDDIVF DSNELLKNCP LVHKFLDPNY ELCWYNALNE PPINVLPNNL
LLANPVNPAD QNGLYSILPI VNGFDISTSK HDNLSNLKKI NDELYKLNDQ IKLFELRGFE
QDLKFNIPDE MITFEQRFHK VIKSLSHLNK IDLKTTKDYK GLINILIDLG GNLNNFSLQI
YQQKKHDLDI DETENVSNQE QSHNDLSETI EKFGSTMDQS FLNFENFVFN QLIPQWQEPV
NQILQYNQTA LNLIKFYKYK IIQFKVLYKL KFNKFQQLVN LNSITGGGNL SSLSSLSSLH
GSGSNGVSGG NGNGETLQAS TSASSFTSAK TDEEEDAVVI NSLDHLKELN SPTLNNALKN
ISLKKVAKKS SWYGLFGGNN QPKKFNFQLP VDESSRPSSN SSPMLGHTQN PTASIKFKLA
HLEKELNKIN QLIELCNDDM MLLTQAIMDT FNEFMRKMEK KWLTIMINYL KNGKALFEEN
LTNWKHFRES FEEVIT
//
